Changes in releasability of ACTH and Beta-endorphin with chronic stress
dc.contributor.author | Young, Elizabeth A. | en_US |
dc.contributor.author | Akil, Huda | en_US |
dc.date.accessioned | 2006-04-07T19:10:14Z | |
dc.date.available | 2006-04-07T19:10:14Z | |
dc.date.issued | 1985-02 | en_US |
dc.identifier.citation | Young, Elizabeth, Akil, Huda (1985/02)."Changes in releasability of ACTH and Beta-endorphin with chronic stress." Neuropeptides 5(4-6): 545-548. <http://hdl.handle.net/2027.42/25776> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WNR-4C48CP3-J0/2/37c5363e6d6a75a3630bb3f48c2506fb | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/25776 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2987742&dopt=citation | en_US |
dc.description.abstract | The activation of the hypothalamic pituitary adrenal axis by stress is well-known. Using inescapable intermittent footshock as a stressor in rats, we have previously demonstrated a rise in circulating plasma Beta-endorphin/Beta-LPH which parallels the rise in plasma ACTH, the primary POMC derived peptides released by anterior lobe. In addition, the rise in ACTH is accompained by approximately a tenfold rise in plasma corticosteroids. Short term anterior lobe pituitary cultures from rats who have received inescapable intermittent footshock for 30 minutes show a blunted dose response curve to the ACTH releasing secretagogues arginine vasopressin (AVP) and ovine corticotropin releasing factor (oCRF). Similarly a blunted dose response curves to secretagogues can be seen by either the addition of dexamethasone (0.5 nM) to the culture medium or pretreatment of the rats with 1 mg dexamethasone intraperitoneally 90 minutes prior to decapitation. Thus, glucocorticoids may play a role in the blunted response to secretagogues seen in anterior lobe cultures from acutely stressed rats. We now report that chronically stressed rats exhibit increased releasability of ACTH and Beta-endorphin/Beta-LPH products by oCRF, suggesting an increase of the peptides in the releasable pool. | en_US |
dc.format.extent | 278122 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Changes in releasability of ACTH and Beta-endorphin with chronic stress | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Mental Health Research Institute, University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Mental Health Research Institute, University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.identifier.pmid | 2987742 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/25776/1/0000337.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0143-4179(85)90075-7 | en_US |
dc.identifier.source | Neuropeptides | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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