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Changes in releasability of ACTH and Beta-endorphin with chronic stress

dc.contributor.authorYoung, Elizabeth A.en_US
dc.contributor.authorAkil, Hudaen_US
dc.date.accessioned2006-04-07T19:10:14Z
dc.date.available2006-04-07T19:10:14Z
dc.date.issued1985-02en_US
dc.identifier.citationYoung, Elizabeth, Akil, Huda (1985/02)."Changes in releasability of ACTH and Beta-endorphin with chronic stress." Neuropeptides 5(4-6): 545-548. <http://hdl.handle.net/2027.42/25776>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WNR-4C48CP3-J0/2/37c5363e6d6a75a3630bb3f48c2506fben_US
dc.identifier.urihttps://hdl.handle.net/2027.42/25776
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2987742&dopt=citationen_US
dc.description.abstractThe activation of the hypothalamic pituitary adrenal axis by stress is well-known. Using inescapable intermittent footshock as a stressor in rats, we have previously demonstrated a rise in circulating plasma Beta-endorphin/Beta-LPH which parallels the rise in plasma ACTH, the primary POMC derived peptides released by anterior lobe. In addition, the rise in ACTH is accompained by approximately a tenfold rise in plasma corticosteroids. Short term anterior lobe pituitary cultures from rats who have received inescapable intermittent footshock for 30 minutes show a blunted dose response curve to the ACTH releasing secretagogues arginine vasopressin (AVP) and ovine corticotropin releasing factor (oCRF). Similarly a blunted dose response curves to secretagogues can be seen by either the addition of dexamethasone (0.5 nM) to the culture medium or pretreatment of the rats with 1 mg dexamethasone intraperitoneally 90 minutes prior to decapitation. Thus, glucocorticoids may play a role in the blunted response to secretagogues seen in anterior lobe cultures from acutely stressed rats. We now report that chronically stressed rats exhibit increased releasability of ACTH and Beta-endorphin/Beta-LPH products by oCRF, suggesting an increase of the peptides in the releasable pool.en_US
dc.format.extent278122 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleChanges in releasability of ACTH and Beta-endorphin with chronic stressen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbsecondlevelChemistryen_US
dc.subject.hlbsecondlevelChemical Engineeringen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelEngineeringen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumMental Health Research Institute, University of Michigan, Ann Arbor, Michigan 48109, USAen_US
dc.contributor.affiliationumMental Health Research Institute, University of Michigan, Ann Arbor, Michigan 48109, USAen_US
dc.identifier.pmid2987742en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/25776/1/0000337.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0143-4179(85)90075-7en_US
dc.identifier.sourceNeuropeptidesen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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