Electrophysiological effects of dynorphin peptides on hippocampal pyramidal cells in rat
dc.contributor.author | Moises, Hylan C. | en_US |
dc.contributor.author | Michael Walker, J. | en_US |
dc.date.accessioned | 2006-04-07T19:10:33Z | |
dc.date.available | 2006-04-07T19:10:33Z | |
dc.date.issued | 1985-01-15 | en_US |
dc.identifier.citation | Moises, Hylan C., Michael Walker, J. (1985/01/15)."Electrophysiological effects of dynorphin peptides on hippocampal pyramidal cells in rat." European Journal of Pharmacology 108(1): 85-98. <http://hdl.handle.net/2027.42/25783> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T1J-478P2KC-6R/2/ea00b5acf6cc75d519ea841ee1f8307a | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/25783 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2858395&dopt=citation | en_US |
dc.description.abstract | Single-unit extracellular recording was carried out in rats to characterize the effects of dynorphin and several structurally related peptides on hippocampal pyramidal cell activity. Dynorphin, applied electrophoretically or by pneumatic pressure, produced a dose-dependent depression of both spontaneous and glutamate-evoked discharge in a majority (63%) of CA1 and CA3 cells tested. In addition, a small number of cells in both cellular fields responded to the peptide with a prolonged elevation in firing. The inhibitory effects of dynorphin in were not blocked by naloxone. Moreover, administration of des-tyrosine-dynorphin depressed the firing of pyramidal cells in a manner similar to that of the parent compound. Ethylketocyclazocine produced a mixed pattern of excitatory and inhibitory effects, whereas naloxone-sensitive elevations in firing were most often observed with the application of dynorphin-(1-8). Application of [Leu5]enkephalin produced only facilitations in pyramidal cell firing. The possibility is raised that biologically significant non-opiate actions, in addition to potent opiate-mediated effects, may occur upon release of pro-dynorphin peptides in the hippocampus. | en_US |
dc.format.extent | 1098069 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Electrophysiological effects of dynorphin peptides on hippocampal pyramidal cells in rat | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Physiology and Mental Health Research Institute, University of Michigan, Ann Arbor, Michigan 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Physiology and Mental Health Research Institute, University of Michigan, Ann Arbor, Michigan 48109, U.S.A. | en_US |
dc.identifier.pmid | 2858395 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/25783/1/0000344.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0014-2999(85)90286-9 | en_US |
dc.identifier.source | European Journal of Pharmacology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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