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Photodiode array ultraviolet spectrophotometric profiling of carboxylic acids in physiological fluids

dc.contributor.authorBuchanan, Douglas N.en_US
dc.contributor.authorThoene, Jess G.en_US
dc.date.accessioned2006-04-07T19:11:01Z
dc.date.available2006-04-07T19:11:01Z
dc.date.issued1985en_US
dc.identifier.citationBuchanan, D. N., Thoene, J. G. (1985)."Photodiode array ultraviolet spectrophotometric profiling of carboxylic acids in physiological fluids." Journal of Chromatography B: Biomedical Sciences and Applications 344(): 23-32. <http://hdl.handle.net/2027.42/25796>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6TG9-44YS1C3-GD/2/ca26f66b7277c80ea3b3a444c21961d4en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/25796
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=4086542&dopt=citationen_US
dc.description.abstractIn this paper the use of a computer-controlled photodiode array spectrophotometric detector for the high-performance liquid chromatographic (HPLC) profiling of carboxylic acids in physiological fluids is reported. The ultraviolet spectrum of the flowing eluent is obtained at 6-sec intervals and is displayed as the absorbance at 190 nm. A three-dimensional (time versus wavelength versus absorbance) presentation of the HPLC profile facilitates peak identification through ultraviolet spectrum matching and relative retention time comparison with carboxylic acid standards. Several examples of HPLC urinary carboxylic acid profiles from infants with various inborn errors of metabolism are shown.en_US
dc.format.extent612192 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titlePhotodiode array ultraviolet spectrophotometric profiling of carboxylic acids in physiological fluidsen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelChemistryen_US
dc.subject.hlbsecondlevelChemical Engineeringen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelEngineeringen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumUniversity of Michigan, Ann Arbor, MI 48109 U.S.A.en_US
dc.contributor.affiliationumUniversity of Michigan, Ann Arbor, MI 48109 U.S.A.en_US
dc.identifier.pmid4086542en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/25796/1/0000358.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/S0378-4347(00)82003-4en_US
dc.identifier.sourceJournal of Chromatography B: Biomedical Sciences and Applicationsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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