Carbon tetrachloride depresses hepatic phospholipid synthesis in rats
dc.contributor.author | Gebhart, Ann Marie W. | en_US |
dc.contributor.author | Brabec, Michael J. | en_US |
dc.date.accessioned | 2006-04-07T19:11:59Z | |
dc.date.available | 2006-04-07T19:11:59Z | |
dc.date.issued | 1985-01 | en_US |
dc.identifier.citation | Gebhart, Ann Marie W., Brabec, Michael J. (1985/01)."Carbon tetrachloride depresses hepatic phospholipid synthesis in rats." Toxicology Letters 24(1): 71-78. <http://hdl.handle.net/2027.42/25820> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6TCR-478C5WM-HJ/2/387e01900f70243fcd566074dc33c5f7 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/25820 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3975932&dopt=citation | en_US |
dc.description.abstract | 40 h after an acute dose of CCl4 (11.3 mmol/kg), the incorporation of [1-3H]ethanolamine into rat hepatic microsomal phospholipids was inhibited to 70% of control. Incorporation into phospholipids of the inner and outer mitochondrial membranes was 30-35% of control. Rates of incorporation were equal to or above normal rates in all membranes 65 h after dosage. The activity of methyltransferase in microsomal fractions isolated from rats 10 to 66 h after dosage was depressed. These data suggest that the alteration of mitochondrial phospholipids that parallels mitochondrial dysfunction after acute CCl4 dosage could be attributed to a CCl4-induced inhibition of the microsomal phospholipid biosynthetic pathways. | en_US |
dc.format.extent | 495056 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Carbon tetrachloride depresses hepatic phospholipid synthesis in rats | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pharmacology, The University of Michigan, Ann Arbor, MI 48109-2029, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Pharmacology, The University of Michigan, Ann Arbor, MI 48109-2029, U.S.A.: Department of Environmental and Industrial Health, Toxicology Program, The University of Michigan, Ann Arbor, MI 48109-2029, U.S.A. | en_US |
dc.identifier.pmid | 3975932 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/25820/1/0000383.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0378-4274(85)90142-0 | en_US |
dc.identifier.source | Toxicology Letters | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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