Magnetic field dependence of spin-lattice relaxation enhancement using piperidinyl nitroxyl spin-labels
dc.contributor.author | Lovin, J. D. | en_US |
dc.contributor.author | Wesbey, G. E. | en_US |
dc.contributor.author | Engelstad, B. L. | en_US |
dc.contributor.author | Sosnovsky, G. | en_US |
dc.contributor.author | Moseley, M. | en_US |
dc.contributor.author | Tuck, D. L. | en_US |
dc.contributor.author | Brasch, R. C. | en_US |
dc.date.accessioned | 2006-04-07T19:12:03Z | |
dc.date.available | 2006-04-07T19:12:03Z | |
dc.date.issued | 1985 | en_US |
dc.identifier.citation | Lovin, J. D., Wesbey, G. E., Engelstad, B. L., Sosnovsky, G., Moseley, M., Tuck, D. L., Brasch, R. C. (1985)."Magnetic field dependence of spin-lattice relaxation enhancement using piperidinyl nitroxyl spin-labels." Magnetic Resonance Imaging 3(1): 73-81. <http://hdl.handle.net/2027.42/25822> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T9D-4BY4SR6-CY/2/b9b0954ca0c139f272a343da63d713f8 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/25822 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3999939&dopt=citation | en_US |
dc.description.abstract | We examined the magnetic resonance properties of 12 paramagnetic piperidinyl nitroxyls in water and plasma solutions. Paramagnetic contributions to proton relaxation times were measured using 10.7 and 100 MHz spectrometers. Proton relaxation enhancement from nitroxyls increased with ascending molecular weight, in plasma solutions versus equimolar aqueous solutions, and with measurements at 10.7 MHz compared to 100 MHz. Relaxation rates were observed to approximately double at 10.7 MHz compared to 100 MHz and from water to plasma solutions. The data indicate that proton spin-lattice relaxation enhancement is magnetic field-dependent, and increases using nitroxyls of large molecular weight and with chemical substitutents that increase the microviscosity of solvent water molecules. The development of nitroxyls for diagnostic MRI will be aided by understanding these in vitro physical characteristics and trends. | en_US |
dc.format.extent | 1078381 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Magnetic field dependence of spin-lattice relaxation enhancement using piperidinyl nitroxyl spin-labels | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Radiology | en_US |
dc.subject.hlbsecondlevel | Family Medicine and Primary Care | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Radiology, University of Michigan, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationother | Contrast Medium Laboratory, Department of Radiology, School of Medicine, University of California, San Francisco, CA 94143, USA | en_US |
dc.contributor.affiliationother | Contrast Medium Laboratory, Department of Radiology, School of Medicine, University of California, San Francisco, CA 94143, USA | en_US |
dc.contributor.affiliationother | The Department of Chemistry, University of Wisconsin, Milwaukee, WI 53201, USA | en_US |
dc.contributor.affiliationother | The Department of Pharmaceutical Chemistry, School of Pharmacy, University of California, San Francisco, CA 94143, USA | en_US |
dc.contributor.affiliationother | The Department of Pharmaceutical Chemistry, School of Pharmacy, University of California, San Francisco, CA 94143, USA: Contrast Medium Laboratory, Department of Radiology, School of Medicine, University of California, San Francisco, CA 94143, USA | en_US |
dc.contributor.affiliationother | Contrast Medium Laboratory, Department of Radiology, School of Medicine, University of California, San Francisco, CA 94143, USA | en_US |
dc.identifier.pmid | 3999939 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/25822/1/0000385.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0730-725X(85)90011-6 | en_US |
dc.identifier.source | Magnetic Resonance Imaging | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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