Inhibition of hepatic aldehyde dehydrogenase by carbon tetrachloride: An in vitro study
dc.contributor.author | Kenel, Michael F. | en_US |
dc.contributor.author | Kulkarni, Arun P. | en_US |
dc.date.accessioned | 2006-04-07T19:15:43Z | |
dc.date.available | 2006-04-07T19:15:43Z | |
dc.date.issued | 1985 | en_US |
dc.identifier.citation | Kenel, M. F., Kulkarni, A. P. (1985)."Inhibition of hepatic aldehyde dehydrogenase by carbon tetrachloride: An in vitro study." International Journal of Biochemistry 17(5): 605-610. <http://hdl.handle.net/2027.42/25916> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B73GR-47F23VV-PH/2/e5e5c769b63e0ccceee8999067d5c6ae | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/25916 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3928415&dopt=citation | en_US |
dc.description.abstract | 1. 1. In vitro inhibition of rat liver mitochondrial and microsomal aldehyde dehydrogenase (ALDH) under conditions of active CCl4 metabolism was investigated.2. 2. Incubation of microsomes or mitochondria in the presence of NADPH alone caused significant, time-dependent inhibition of mitochondrial and microsomal ALDH. EDTA partially protected ALDH from inhibition.3. 3. Incubation of microsomes or microsomes plus mitochondria in the presence of NADPH and CCl4 resulted in marked inhibition of microsomal and mitochondrial ALDH activity. The inhibition was both dose- and time-dependent and was relatively less in the presence of EDTA.4. 4. It is proposed that the inhibition of membrane-bound ALDH may be one of the early events responsible for the genesis of CCl4-hepatotoxicity. | en_US |
dc.format.extent | 562876 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Inhibition of hepatic aldehyde dehydrogenase by carbon tetrachloride: An in vitro study | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Toxicology Program, Department of Environmental and Industrial Health, School of Public Health, University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Toxicology Program, Department of Environmental and Industrial Health, School of Public Health, University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.identifier.pmid | 3928415 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/25916/1/0000479.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0020-711X(85)90292-7 | en_US |
dc.identifier.source | International Journal of Biochemistry | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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