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Absence of xanthine oxidase or xanthine dehydrogenase in the rabbit myocardium
dc.contributor.authorGrum, Cyril M.en_US
dc.contributor.authorRagsdale, Richard A.en_US
dc.contributor.authorKetai, Loren H.en_US
dc.contributor.authorShlafer, Marshalen_US
dc.date.accessioned2006-04-07T19:22:25Z
dc.date.available2006-04-07T19:22:25Z
dc.date.issued1986-12-30en_US
dc.identifier.citationGrum, Cyril M., Ragsdale, Richard A., Ketai, Loren H., Shlafer, Marshal (1986/12/30)."Absence of xanthine oxidase or xanthine dehydrogenase in the rabbit myocardium." Biochemical and Biophysical Research Communications 141(3): 1104-1108. <http://hdl.handle.net/2027.42/25939>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WBK-4FW0C1P-RT/2/05f1e3ea1a43855b528a1abc059cae00en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/25939
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3468948&dopt=citationen_US
dc.description.abstractWe directly measured the activity of the enzymes xanthine oxidase and xanthine dehydrogenase in rabbit and rat hearts, using a sensitive radio-chemical assay. Neither xanthine oxidase activity nor xanthine dehydrogenase activity was detected in the rabbit heart. In the rat heart, xanthine oxidase activity was 9.1 [plus-or-minus sign] 0.5 mIU per gram wet weight and xanthine dehydrogenase activity was 53.0 [plus-or-minus sign] 1.9 mIU per gram wet weight. These results argue against the involvement of the xanthine oxidase/xanthine dehydrogenase system as a mechanism of tissue injury in the rabbit heart, and suggest that the ability of allopurinol to protect the rabbit heart against hypoxic or ischemic damage must be due to a mechanism other than inhibition of these enzymes.en_US
dc.format.extent328123 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleAbsence of xanthine oxidase or xanthine dehydrogenase in the rabbit myocardiumen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNatural Resources and Environmenten_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelEcology and Evolutionary Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Internal Medicine (Pulmonary & Critical Care Medicine Division), The University of Michigan Medical Center Ann Arbor, MI 48109, USAen_US
dc.contributor.affiliationumDepartment of Internal Medicine (Pulmonary & Critical Care Medicine Division), The University of Michigan Medical Center Ann Arbor, MI 48109, USAen_US
dc.contributor.affiliationumDepartment of Internal Medicine (Pulmonary & Critical Care Medicine Division), The University of Michigan Medical Center Ann Arbor, MI 48109, USAen_US
dc.contributor.affiliationumDepartments of Pharmacology and Surgery (Thoracic Section), University of Michigan Medical Center Ann Arbor, MI 48109, USAen_US
dc.identifier.pmid3468948en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/25939/1/0000001.pdfen_US
dc.identifier.sourceBiochemical and Biophysical Research Communicationsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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