Plasma levels of immunoreactive atrial natriuretic hormone in patients with diabetes mellitus
dc.contributor.author | Kahn, Joel K. | en_US |
dc.contributor.author | Grekin, Roger J. | en_US |
dc.contributor.author | Shenker, Yoram | en_US |
dc.contributor.author | Vinik, Aaron I. | en_US |
dc.date.accessioned | 2006-04-07T19:24:47Z | |
dc.date.available | 2006-04-07T19:24:47Z | |
dc.date.issued | 1986-11 | en_US |
dc.identifier.citation | Kahn, Joel K., Grekin, Roger J., Shenker, Yoram, Vinik, Aaron I. (1986/11)."Plasma levels of immunoreactive atrial natriuretic hormone in patients with diabetes mellitus." Regulatory Peptides 15(4): 323-332. <http://hdl.handle.net/2027.42/25997> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T0S-47TG8NM-CV/2/f9ce55d5ffd4433f34859acfa32e8898 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/25997 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2948221&dopt=citation | en_US |
dc.description.abstract | In order to determine whether atrial natriuretic hormone (ANH) secretion is altered in diabetic patients with autonomic neuropathy, plasma immunoreactive ANH (IR-ANH) levels were measured in 23 patients with insulin-dependent diabetes mellitus, 12 of whom had definite cardiac autonomic neuropathy determined by noninvasive maneuvers. Levels were also measured in 31 healthy control subjects. Whereas only one of the 11 diabetics without cardiac autonomic neuropathy had elevated IR-ANH levels, four of the 12 diabetics with cardiac autonomic neuropathy had elevated IR-ANH levels (P = 0.03 compared to control subjects). 24-h urinary sodium excetion was not different among the groups. There was no significant correlation between IR-ANH levels and diabetes control and any of the parameters of autonomic nervous system activity nor between IR-ANH levels and plasma norepinephrine or epinephrine levels. Furthermore, no relationship was observed in the diabetic subjects between IR-ANH levels and left ventricular ejection fraction determined by radionuclide ventriculography. Thus, elevated IR-ANH levels occur with greater frequency in diabetic patients with autonomic neuropathy. These elevations do not appear to be due to alterations in dietary sodium intake or left ventricular dysfunction. | en_US |
dc.format.extent | 537120 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Plasma levels of immunoreactive atrial natriuretic hormone in patients with diabetes mellitus | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Division of Endocrinology and Metabolism, Department of Surgery, University of Michigan, Ann Arbor, Michigan, U.S.A.: Veterans Administration Medical Centers, Ann Arbor, Michigan, U.S.A.: Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, U.S.A. | en_US |
dc.contributor.affiliationum | Division of Endocrinology and Metabolism, Department of Surgery, University of Michigan, Ann Arbor, Michigan, U.S.A.: Veterans Administration Medical Centers, Ann Arbor, Michigan, U.S.A.: Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, U.S.A. | en_US |
dc.contributor.affiliationum | Division of Endocrinology and Metabolism, Department of Surgery, University of Michigan, Ann Arbor, Michigan, U.S.A.: Veterans Administration Medical Centers, Ann Arbor, Michigan, U.S.A.: Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, U.S.A. | en_US |
dc.contributor.affiliationum | Division of Endocrinology and Metabolism, Department of Surgery, University of Michigan, Ann Arbor, Michigan, U.S.A.: Veterans Administration Medical Centers, Ann Arbor, Michigan, U.S.A.: Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, U.S.A. | en_US |
dc.identifier.pmid | 2948221 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/25997/1/0000063.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0167-0115(86)90162-X | en_US |
dc.identifier.source | Regulatory Peptides | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.