A dog model using an implanted system for protracted hepatic arterial chemotherapy
dc.contributor.author | Wollner, I. S. | en_US |
dc.contributor.author | Knutsen, Conrad A. | en_US |
dc.contributor.author | Ullrich, K. A. | en_US |
dc.contributor.author | Niederhuber, John E. | en_US |
dc.contributor.author | Crudup, James W. | en_US |
dc.contributor.author | Juni, Jack E. | en_US |
dc.contributor.author | Warber, S. L. | en_US |
dc.contributor.author | Gyves, John W. | en_US |
dc.contributor.author | Stetson, Phillip L. | en_US |
dc.contributor.author | Ensminger, William D. | en_US |
dc.date.accessioned | 2006-04-07T19:24:51Z | |
dc.date.available | 2006-04-07T19:24:51Z | |
dc.date.issued | 1986-11 | en_US |
dc.identifier.citation | Wollner, I. S., Knutsen, C. A., Ullrich, K. A., Niederhuber, J. E., Crudup, J. W., Juni, J. E., Warber, S. L., Gyves, J., Stetson, P. L., Ensminger, W. D. (1986/11)."A dog model using an implanted system for protracted hepatic arterial chemotherapy." Journal of Surgical Research 41(5): 510-517. <http://hdl.handle.net/2027.42/25999> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WM6-4BNF3WT-2J8/2/fd8f38972c5d9897e74a4f3c3b054dd6 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/25999 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3773508&dopt=citation | en_US |
dc.description.abstract | A model for hepatic arterial chemotherapy studies using large dogs and an implantable infusion pump has been developed. Using this technique near complete perfusion (>90%) of the liver can be achieved in vivo as determined by hepatic arterial perfusion scintigraphy with technitium 99m macroaggregated albumin. The system is reliable and has been in use for a total of 1353 days (mean of 104 days, range 52-239) in 13 dogs. Pump implantation causes no apparent acute liver damage based on pre- and post-operative alkaline phosphatase and serum glutamic-pyruvic transaminase determinations and does not affect the general mobility or behavior of the animals. Careful placement of the catheter and attention to the physicochemical properties of the solutions loaded are factors contributing to the success of the model. The model permits comprehensive preclinical pharmacokinetic and toxicologic studies of new or preexistent chemotherapeutic agents in the same device that will be used for later administration in human subjects. By providing the means to examine and develop new treatment modalities, it enables the design of even more potent cytotoxic therapy directed into the tumor vascular bed. | en_US |
dc.format.extent | 692420 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | A dog model using an implanted system for protracted hepatic arterial chemotherapy | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Surgery and Anesthesiology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA: Upjohn Center for Clinical Pharmacology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Upjohn Center for Clinical Pharmacology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Upjohn Center for Clinical Pharmacology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Department of Surgery, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Department of Surgery, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA: Upjohn Center for Clinical Pharmacology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Upjohn Center for Clinical Pharmacology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Upjohn Center for Clinical Pharmacology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA: Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA | en_US |
dc.identifier.pmid | 3773508 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/25999/1/0000065.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0022-4804(86)90169-1 | en_US |
dc.identifier.source | Journal of Surgical Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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