The glutamate analogue quisqualic acid is neurotoxic in striatum and hippocampus of immature rat brain
dc.contributor.author | Silverstein, Faye Sarah | en_US |
dc.contributor.author | Chen, Ronni | en_US |
dc.contributor.author | Johnston, Michael V. | en_US |
dc.date.accessioned | 2006-04-07T19:25:12Z | |
dc.date.available | 2006-04-07T19:25:12Z | |
dc.date.issued | 1986-10-30 | en_US |
dc.identifier.citation | Silverstein, Faye S., Chen, Ronni, Johnston, Michael V. (1986/10/30)."The glutamate analogue quisqualic acid is neurotoxic in striatum and hippocampus of immature rat brain." Neuroscience Letters 71(1): 13-18. <http://hdl.handle.net/2027.42/26009> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T0G-485RKNF-DD/2/0ce722ce584134329c9d6b0a31424ef0 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/26009 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3024070&dopt=citation | en_US |
dc.description.abstract | To assess the neurotoxic properties of the glutamate agonist quisqualic acid (QA) in immature brain, we injected this compound (100 nmol QA/l [mu]l) directly into the striatum of 7-day-old rats. QA produced neuronal necrosis and glial infiltration in 14 pups and reduced the size of the striatum and hippocampus on the side of injection. Intracerebral injection of QA provides a new method for producing neuronal lesions in the developing brain. | en_US |
dc.format.extent | 414613 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | The glutamate analogue quisqualic acid is neurotoxic in striatum and hippocampus of immature rat brain | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Psychology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Social Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, U.S.A.; Center for Human Growth and Development, University of Michigan, Ann Arbor, MI, U.S.A. | en_US |
dc.contributor.affiliationum | Center for Human Growth and Development, University of Michigan, Ann Arbor, MI, U.S.A.; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Neurology, University of Michigan Medical School, Ann Arbor, MI, U.S.A.; Center for Human Growth and Development, University of Michigan, Ann Arbor, MI, U.S.A.; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, U.S.A. | en_US |
dc.identifier.pmid | 3024070 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/26009/1/0000076.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0304-3940(86)90249-1 | en_US |
dc.identifier.source | Neuroscience Letters | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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