Prediction of protein function by discriminant analysis
dc.contributor.author | Klein, Petr | en_US |
dc.contributor.author | Jacquez, John A. | en_US |
dc.contributor.author | Delisi, Charles | en_US |
dc.date.accessioned | 2006-04-07T19:25:45Z | |
dc.date.available | 2006-04-07T19:25:45Z | |
dc.date.issued | 1986-10 | en_US |
dc.identifier.citation | Klein, Petr, Jacquez, John A., Delisi, Charles (1986/10)."Prediction of protein function by discriminant analysis." Mathematical Biosciences 81(2): 177-189. <http://hdl.handle.net/2027.42/26024> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6VHX-45F51W5-3X/2/c846f46acb7e497f7ae0412a5d6d59d8 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/26024 | |
dc.description.abstract | Approximately 53% the protein sequences in the National Biomedical Research Foundation (NBRF) database can be allocated to one of 26 functional classes, each of which can be characterized by the joint occurrence of four or fewer attributes. The attributes reflect collective physicochemical properties of the sequences in a class, ranging from simple characteristics of composition, such as average hydrophobicity and net charge, to amphipathicity and the propensities of various residues to be in certain preferred configurations. In some, though not all instances, these variables can be related in a general way to topological or other structural features of the particular class they characterize. We show that the attributes permit 17 of the 26 groups to be filtered from all other proteins in the database with a misclassification error of less than 2%, and that the remaining 9 groups can be filtered with errors not exceeding 13%. Thus for a given functional class, the results point to the existence of relatively few characteristic variables which capture most of the intraclass similarity and interclass variability that is common and peculiar to members of that class. | en_US |
dc.format.extent | 773339 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Prediction of protein function by discriminant analysis | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Statistics and Numeric Data | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Mathematics | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Social Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Physiology, The University of Michigan, Ann Arbor, Michigan 48109, U.S.A. | en_US |
dc.contributor.affiliationother | Division of Biological Sciences, National Research Council, Ottawa, Ontario, Canada KIA OR6 | en_US |
dc.contributor.affiliationother | Laboratory of Mathematical Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205, U.S.A. | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/26024/1/0000096.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0025-5564(86)90116-1 | en_US |
dc.identifier.source | Mathematical Biosciences | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.