Generation of drug metabolite antigenicity in the intestinal mucosa
dc.contributor.author | Chung Wu, | en_US |
dc.contributor.author | Mathews, Kenneth P. | en_US |
dc.date.accessioned | 2006-04-07T19:27:36Z | |
dc.date.available | 2006-04-07T19:27:36Z | |
dc.date.issued | 1986-08 | en_US |
dc.identifier.citation | Chung Wu, , Mathews, Kenneth P. (1986/08)."Generation of drug metabolite antigenicity in the intestinal mucosa." Immunopharmacology 12(1): 53-58. <http://hdl.handle.net/2027.42/26077> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T27-475BBK0-8/2/a3b2e6ae5985903db185e54ea572a0ff | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/26077 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2875976&dopt=citation | en_US |
dc.description.abstract | Both nitroreductase and transglutaminase activities have been assayed in the 10 000 x g supernatant fluids of rat intestine homogenates after Triton X-100 treatment. Incubation of 14C-nitrofurantoin in the intestine extract yielded protein-bound 14C-labeled products. Injection into rabbits of the conjugated protein similarly prepared with unlabeled nitrofurantoin elicited formation of antibodies against nitrofurantoin. These results suggest that intestinal metabolism and conjugation to protein of orally administered drugs may serve as a probable mechanism of drug allergy, and this may be accomplished by enzymatic coupling of relatively stable drug metabolites to protein carriers. | en_US |
dc.format.extent | 446283 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Generation of drug metabolite antigenicity in the intestinal mucosa | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Microbiology and Immunology | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Biological Chemistry and Montgomery Allergy Research Laboratory, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Biological Chemistry and Montgomery Allergy Research Laboratory, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.identifier.pmid | 2875976 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/26077/1/0000153.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0162-3109(86)90051-2 | en_US |
dc.identifier.source | Immunopharmacology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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