Electrophysiological effects of prazosin during acute myocardial ischemia
dc.contributor.author | Wilber, David J. | en_US |
dc.contributor.author | Lynch, Joseph J. | en_US |
dc.contributor.author | Lucchesi, Benedict Robert | en_US |
dc.date.accessioned | 2006-04-07T19:27:51Z | |
dc.date.available | 2006-04-07T19:27:51Z | |
dc.date.issued | 1986-08 | en_US |
dc.identifier.citation | Wilber, David J., Lynch, Joseph J., Lucchesi, Benedict R. (1986/08)."Electrophysiological effects of prazosin during acute myocardial ischemia." European Journal of Pharmacology 127(1-2): 157-161. <http://hdl.handle.net/2027.42/26081> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T1J-475SKKW-7M/2/077a2ec4fe1905ec10cdd421e1ddd348 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/26081 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3019724&dopt=citation | en_US |
dc.description.abstract | Prazosin, 100 [mu]g/kg, had no effect on baseline refractoriness or intraventricular conduction in anesthetized dogs. During 1 h of coronary artery occlusion followed by reperfusion, prazosin significantly blunted the shortening of the ventricular effective refractory periods within ischemic myocardial region relative to vehicle-treated animals. Prazosin treatment also prevented the delayed conduction of paced ventricular complexes entering and exiting the ischemic zone. These effects may be associated with the blockade of [alpha]1-adrenoceptor activation during the acute phase of myocardial ischemia. | en_US |
dc.format.extent | 442951 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Electrophysiological effects of prazosin during acute myocardial ischemia | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Departments of Pharmacology and Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-0010, U.S.A | en_US |
dc.contributor.affiliationum | Departments of Pharmacology and Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-0010, U.S.A | en_US |
dc.contributor.affiliationum | Departments of Pharmacology and Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-0010, U.S.A | en_US |
dc.identifier.pmid | 3019724 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/26081/1/0000157.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0014-2999(86)90220-7 | en_US |
dc.identifier.source | European Journal of Pharmacology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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