Nerve growth factor increases choline acetyltransferase activity in developing basal forebrain neurons
dc.contributor.author | Mobley, William C. | en_US |
dc.contributor.author | Rutkowski, J. Lynn | en_US |
dc.contributor.author | Tennekoon, Gihan I. | en_US |
dc.contributor.author | Gemski, Jude | en_US |
dc.contributor.author | Buchanan, Karen | en_US |
dc.contributor.author | Johnston, Michael V. | en_US |
dc.date.accessioned | 2006-04-07T19:28:50Z | |
dc.date.available | 2006-04-07T19:28:50Z | |
dc.date.issued | 1986-07 | en_US |
dc.identifier.citation | Mobley, William C., Rutkowski, J. Lynn, Tennekoon, Gihan I., Gemski, Jude, Buchanan, Karen, Johnston, Michael V. (1986/07)."Nerve growth factor increases choline acetyltransferase activity in developing basal forebrain neurons." Molecular Brain Research 1(1): 53-62. <http://hdl.handle.net/2027.42/26109> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T07-484NBS7-8/2/ab961e9cffb0f747d3228017b5445bd8 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/26109 | |
dc.description.abstract | Nerve growth factor (NGF) is a neuronotrophic protein. Its effects on developing peripheral sensory and sympathetic neurons have been extensively characterized, but it is not clear whether NGF plays a role during the development of central nervous system neurons. To address this point, we examined the effect of NGF on the activity of neurotransmitter enzymes in several brain regions. Intracerebroventricular injections of highly purified mouse NGF had a marked effect on the activity of choline acetyltransferase (ChAT), a selective marker of cholinergic neurons. NGF elicited prominent increases in ChAT activity in the basal forebrain of neonatal rats, including the septum and a region which contains neurons of the nucleus basalis and substantia innominata. NGF also increased ChAT activity in the hippocampus and neocortex, terminal regions for the fibers of basal forebrain cholinergic neurons. In analogy with the response of developing peripheral neurons, the NGF effect was shown to be selective for basal forebrain cholinergic cells and to be dose-dependent. Furthermore, septal neurons closely resembled sympathetic neurons in the time course of their response to NGF. These observations suggest that endogenous NGF does play a role in the development of basal forebrain cholinergic neurons. | en_US |
dc.format.extent | 823700 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Nerve growth factor increases choline acetyltransferase activity in developing basal forebrain neurons | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Psychology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Social Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Departments of Pediatrics and Neurology and Center for Human Growth and Development, University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Departments of Pediatrics and Neurology and Center for Human Growth and Development, University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationother | Neuropharmacology Branch, Department of Medical Neurosciences, Walter Reed Army Institute of Research, Washington, DC 20307, U.S.A.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, U.S.A. | en_US |
dc.contributor.affiliationother | Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, U.S.A. | en_US |
dc.contributor.affiliationother | Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, U.S.A. | en_US |
dc.contributor.affiliationother | Waters Associates, Life Sciences Application Laboratory, Rockville, MD 20852, U.S.A. | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/26109/1/0000185.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0169-328X(86)90020-3 | en_US |
dc.identifier.source | Molecular Brain Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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