Laminin supports neurite outgrowth from explants of axotomized adult rat retinal neurons
dc.contributor.author | Ford-Holevinski, Thomas S. | en_US |
dc.contributor.author | Hopkins, James M. | en_US |
dc.contributor.author | McCoy, J. Philip Jr. | en_US |
dc.contributor.author | Agranoff, Bernard W. | en_US |
dc.date.accessioned | 2006-04-07T19:28:59Z | |
dc.date.available | 2006-04-07T19:28:59Z | |
dc.date.issued | 1986-07 | en_US |
dc.identifier.citation | Ford-Holevinski, Thomas S., Hopkins, James M., Philip McCoy, J., Agranoff, Bernard W. (1986/07)."Laminin supports neurite outgrowth from explants of axotomized adult rat retinal neurons." Developmental Brain Research 28(1): 121-126. <http://hdl.handle.net/2027.42/26113> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6SYW-4840MKF-3M/2/28629fb4e1e814f56996b8436ca857b3 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/26113 | |
dc.description.abstract | The influence of laminin on neurite outgrowth from explants of adult rat retina and its distribution in normal and lesioned rat optic nerves were examined. Neurite outgrowth required the presence of laminin in the substratum, and as with a goldfish retinal explant system, was markedly stimulated by prior axotomy. Except for blood vessels and the nerve sheath, normal rat optic nerve was devoid of laminin immunoreactivity. Unlike results seen in the goldfish optic nerve, injury to the rat optic nerve induced no observable increase in laminin content or change in its distribution. The differences in the in vivo regenerative capacities of these two species may in part be related to the differences in their abilities to provide a proper substratum for axon regrowth. | en_US |
dc.format.extent | 731137 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Laminin supports neurite outgrowth from explants of axotomized adult rat retinal neurons | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Psychology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Social Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Mental Health Research Institute and Departments of Biological Chemistry, University of Michigan, Ann Arbor, MI 48104, U.S.A. | en_US |
dc.contributor.affiliationum | Mental Health Research Institute and Departments of Biological Chemistry, University of Michigan, Ann Arbor, MI 48104, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan, Ann Arbor, MI 48104, U.S.A. | en_US |
dc.contributor.affiliationum | Mental Health Research Institute and Departments of Biological Chemistry, University of Michigan, Ann Arbor, MI 48104, U.S.A. | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/26113/1/0000189.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0165-3806(86)90071-4 | en_US |
dc.identifier.source | Developmental Brain Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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