Convulsions may alter the specificity of kappa-opiate receptors
dc.contributor.author | Mansour, Alfred | en_US |
dc.contributor.author | Valenstein, Elliot S. | en_US |
dc.date.accessioned | 2006-04-07T19:30:31Z | |
dc.date.available | 2006-04-07T19:30:31Z | |
dc.date.issued | 1986-06 | en_US |
dc.identifier.citation | Mansour, Alfred, Valenstein, Elliot S. (1986/06)."Convulsions may alter the specificity of kappa-opiate receptors." Experimental Neurology 92(3): 571-582. <http://hdl.handle.net/2027.42/26156> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WFG-4C8H7HR-8M/2/95b29be14d705fba0667d6d984ccdf7f | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/26156 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3011487&dopt=citation | en_US |
dc.description.abstract | Morphine, a mu-opiate agonist, and ethylketazocine, a kappa-opiate agonist, produce distinct behavioral, pharmacologic, and biochemical effects. In the mouse, large doses of morphine produce convulsions that are usually lethal and that cannot be blocked by naltrexone, whereas ethylketazocine produces nonlethal clonic convulsions that can be blocked by naltrexone. Moreover, mice made tolerant to morphine failed to show cross-tolerance to ethylketazocine, suggesting that the convulsions induced by these drugs are not mediated via a common opioid mechanism. Following a series of electroconvulsive shocks, both morphine and ethylketazocine produced clonic convulsions that were not lethal and that could be blocked by naltrexone. Furthermore, electroconvulsive shock-treated animals made tolerant to morphine-induced convulsions showed cross-tolerance to ethylketazocine. These data suggest that eletroconvulsive shock may alter kappa-opioid systems in such a way as to allow mu-agonists to be functional at these sites. | en_US |
dc.format.extent | 755235 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Convulsions may alter the specificity of kappa-opiate receptors | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Psychology, The University of Michigan, Ann Arbor, Michigan 48109, USA; Neuroscience Laboratory, The University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Department of Psychology, The University of Michigan, Ann Arbor, Michigan 48109, USA; Neuroscience Laboratory, The University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.identifier.pmid | 3011487 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/26156/1/0000233.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0014-4886(86)90299-2 | en_US |
dc.identifier.source | Experimental Neurology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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