Regulation of macrophage tumor necrosis factor production by prostaglandin E2
dc.contributor.author | Kunkel, Steven L. | en_US |
dc.contributor.author | Wiggins, Roger C. | en_US |
dc.contributor.author | Chensue, Stephen W. | en_US |
dc.contributor.author | Larrick, James W. | en_US |
dc.date.accessioned | 2006-04-07T19:30:52Z | |
dc.date.available | 2006-04-07T19:30:52Z | |
dc.date.issued | 1986-05-29 | en_US |
dc.identifier.citation | Kunkel, S. L., Wiggins, R. C., Chensue, S. W., Larrick, J. (1986/05/29)."Regulation of macrophage tumor necrosis factor production by prostaglandin E2." Biochemical and Biophysical Research Communications 137(1): 404-410. <http://hdl.handle.net/2027.42/26166> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WBK-4DXRY44-1CK/2/8ad8feac4d15c52e5176b60fb640ac82 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/26166 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3459461&dopt=citation | en_US |
dc.description.abstract | We have studied the role of prostaglandin E2 on the modulation of tumor necrosis factor by immunologically elicited and lipopolysaccharide treated murine macrophages. Indomethacin, a potent inhibitor of prostaglandin E2 production, caused a dose dependent augmentation of lipopolysaccharide induced tumor necrosis factor production (2-3 fold at 10-7 molar). Tumor necrosis factor was released into the extracellular environment and no activity was found to be associated with membrane or cytosolic fractions. Prostaglandin E2 added to the lipopolysaccharide treated cultures suppressed tumor necrosis factor in a dose dependent manner. In these studies, 10-7 molar PGE2 reduced tumor necrosis factor production to basal levels. These data suggest that PGE2 may be a potent autoregulatory factor that dramatically influences tumor necrosis factor production. | en_US |
dc.format.extent | 424099 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Regulation of macrophage tumor necrosis factor production by prostaglandin E2 | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pathology University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Internal Medicine University of Michigan Medical School, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Department of Pathology University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Internal Medicine University of Michigan Medical School, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Department of Pathology University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Internal Medicine University of Michigan Medical School, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationother | Cetus Immune Corporation, Palo Alto, California 94303, USA | en_US |
dc.identifier.pmid | 3459461 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/26166/1/0000243.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0006-291X(86)91224-6 | en_US |
dc.identifier.source | Biochemical and Biophysical Research Communications | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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