Role for aldosterone in blood pressure regulation of obese adolescents
dc.contributor.author | Rocchini, Albert P. | en_US |
dc.contributor.author | Katch, Victor L. | en_US |
dc.contributor.author | Grekin, Roger J. | en_US |
dc.contributor.author | Moorehead, Catherine P. | en_US |
dc.contributor.author | Anderson, Judith | en_US |
dc.date.accessioned | 2006-04-07T19:31:00Z | |
dc.date.available | 2006-04-07T19:31:00Z | |
dc.date.issued | 1986-05-03 | en_US |
dc.identifier.citation | Rocchini, Albert P., Katch, Victor L., Grekin, Roger, Moorehead, Catherine, Anderson, Judith (1986/05/03)."Role for aldosterone in blood pressure regulation of obese adolescents." The American Journal of Cardiology 57(8): 613-618. <http://hdl.handle.net/2027.42/26170> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T10-4C76CMX-YD/2/2961ab9e15ed54d5f3245d2d4ff8f4ce | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/26170 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3513521&dopt=citation | en_US |
dc.description.abstract | To determine the role of aldosterone in the regulation of blood pressure (BP) in obese adolescents, supine and 2-hour upright plasma renin activity (PRA), and aldosterone and cortisol were measured in 10 nonobese and 30 obese adolescents before and after a 20-week weight loss program. The obese adolescents had significantly higher supine and 2-hour upright plasma aldosterone concentrations (17 +/- 8 vs 6 +/- 2 ng/dl [p < 0.01 supine obese vs nonobese] and 30 +/- 11 vs 14 +/- 8 ng/dl [p < 0.01 2-hour upright]). Although PRA was not significantly different between the 2 groups of children, a given increment in PRA produced a greater increment in aldosterone in the obese adolescents. In addition, obese subjects had a significantly increased mean BP (93 +/- 12 vs 74 +/- 8, p < 0.005) and a weak correlation between BP and plasma aldosterone concentration. Compared with an obese control group, weight loss resulted in a significant decrease in plasma aldosterone (p < 0.01) without an associated decrease in PRA. After weight loss there was also a significant decrease in the slope of the posture-induced relation between PRA and aldosterone. In addition to weight loss being associated with a significant decrease in BP (p < 0.01), there was a significant correlation between the change in plasma aldosterone and the change in mean BP (r = 0.538; p < 0.002 change in upright aldosterone vs change in mean BP). Obese adolescents have an increased plasma aldosterone concentration that may be important in the regulation of their BP. | en_US |
dc.format.extent | 650959 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Role for aldosterone in blood pressure regulation of obese adolescents | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Section of Pediatric Cardiology, C.S. Mott Children's Hospital, Ann Arbor, Michigan, U.S.A.; Departments of Pediatrics and Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, U.S.A. | en_US |
dc.contributor.affiliationum | Departments of Pediatrics and Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, U.S.A.; Section of Pediatric Cardiology, C.S. Mott Children's Hospital, Ann Arbor, Michigan, U.S.A. | en_US |
dc.contributor.affiliationum | Departments of Pediatrics and Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, U.S.A.; Section of Pediatric Cardiology, C.S. Mott Children's Hospital, Ann Arbor, Michigan, U.S.A. | en_US |
dc.contributor.affiliationum | Departments of Pediatrics and Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, U.S.A.; Section of Pediatric Cardiology, C.S. Mott Children's Hospital, Ann Arbor, Michigan, U.S.A. | en_US |
dc.contributor.affiliationum | Departments of Pediatrics and Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, U.S.A.; Section of Pediatric Cardiology, C.S. Mott Children's Hospital, Ann Arbor, Michigan, U.S.A. | en_US |
dc.identifier.pmid | 3513521 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/26170/1/0000247.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0002-9149(86)90845-3 | en_US |
dc.identifier.source | The American Journal of Cardiology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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