Evaluation of chronic toxicity and carcinogenesis in rodents with the synthetic analgesic, tilidine fumarate
dc.contributor.author | McGuire, Edward J. | en_US |
dc.contributor.author | DiFonzo, Carlo J. | en_US |
dc.contributor.author | Martin, Ronald A. | en_US |
dc.contributor.author | de la Iglesia, Felix A. | en_US |
dc.date.accessioned | 2006-04-07T19:31:09Z | |
dc.date.available | 2006-04-07T19:31:09Z | |
dc.date.issued | 1986-05 | en_US |
dc.identifier.citation | McGuire, Edward J., DiFonzo, Carlo J., Martin, Ronald A., De La Iglesia, Felix A. (1986/05)."Evaluation of chronic toxicity and carcinogenesis in rodents with the synthetic analgesic, tilidine fumarate." Toxicology 39(2): 149-163. <http://hdl.handle.net/2027.42/26174> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6TCN-479CRFX-56/2/133f6b4e67accb484cc51afc79f90507 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/26174 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3705081&dopt=citation | en_US |
dc.description.abstract | The carcinogenic potential of tilidine fumarate, a synthetic analgesic, was studied for 80 and 104 weeks in mice and rats, respectively. Groups of 50 albino CF1 mice and 65 albino Wistar rats of each sex received tilidine fumarate-lactose blend (1:1) at doses of 100, 40 and 16 mg/kg. The control groups consisted of 100 mice and 115 rats of each sex and received the lactose vehicle only. Treatment-related non-neoplastic changes consisted of reversible, increased cytoplasmic eosinophilia of hepatocytes in high and mid dose rats corresponding to areas of proliferating smooth endoplasmic reticulum; and an increased in high dose rats of proliferative or cystic lesions of the biliary epithelium. Adequate survival rates allowed stringent statistical analysis of neoplasia. Tilidine did not evoke increased tumor incidences or changes in teh average latency or onset of tumors in either species. The most frequent tumors represented spontaneous neoplasia characteristic of historical background incidence in these strains. In mice, the only statistically significant (P P < 0.01) decreased incidences of mammary fibroadenoma and pituitary adenoma. From these data, it was concluded that the synthetic analgesic tilidine does not possess tumorigenic potential in rodents. | en_US |
dc.format.extent | 766583 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Evaluation of chronic toxicity and carcinogenesis in rodents with the synthetic analgesic, tilidine fumarate | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pathology and Experimental Toxicology, Warner-Lambert/Parke-Davis Pharmaceutical Research, Ann Arbor, MI 48105, USA; Warner-Lambert/Parke-Davis Research Institute, Mississauga, Ontario, Canada; Department of Environmental and Industrial Health Sciences, School of Public Health, University of Michigan, Ann Harbor, MI 48109, USA. | en_US |
dc.contributor.affiliationum | Warner-Lambert/Parke-Davis Research Institute, Mississauga, Ontario, Canada; Department of Environmental and Industrial Health Sciences, School of Public Health, University of Michigan, Ann Harbor, MI 48109, USA; Department of Pathology and Experimental Toxicology, Warner-Lambert/Parke-Davis Pharmaceutical Research, Ann Arbor, MI 48105, USA. | en_US |
dc.contributor.affiliationum | Warner-Lambert/Parke-Davis Research Institute, Mississauga, Ontario, Canada; Department of Environmental and Industrial Health Sciences, School of Public Health, University of Michigan, Ann Harbor, MI 48109, USA; Department of Pathology and Experimental Toxicology, Warner-Lambert/Parke-Davis Pharmaceutical Research, Ann Arbor, MI 48105, USA. | en_US |
dc.contributor.affiliationum | Warner-Lambert/Parke-Davis Research Institute, Mississauga, Ontario, Canada; Department of Environmental and Industrial Health Sciences, School of Public Health, University of Michigan, Ann Harbor, MI 48109, USA; Department of Pathology and Experimental Toxicology, Warner-Lambert/Parke-Davis Pharmaceutical Research, Ann Arbor, MI 48105, USA. | en_US |
dc.identifier.pmid | 3705081 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/26174/1/0000253.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0300-483X(86)90132-0 | en_US |
dc.identifier.source | Toxicology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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