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Intrathecal bombesin-induced inhibition of gastrointestinal transit: requirement for an intact pituitary-adrenal axis
dc.contributor.authorKoslo, Randy J.en_US
dc.contributor.authorGmerek, Debra E.en_US
dc.contributor.authorCowan, Alanen_US
dc.contributor.authorPorreca, Franken_US
dc.date.accessioned2006-04-07T19:31:13Z
dc.date.available2006-04-07T19:31:13Z
dc.date.issued1986-05en_US
dc.identifier.citationKoslo, Randy J., Gmerek, Debra E., Cowan, Alan, Porreca, Frank (1986/05)."Intrathecal bombesin-induced inhibition of gastrointestinal transit: requirement for an intact pituitary-adrenal axis." Regulatory Peptides 14(3): 237-242. <http://hdl.handle.net/2027.42/26176>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T0S-47TG505-B6/2/e026422924bf518c297b6229292b7679en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/26176
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3755251&dopt=citationen_US
dc.description.abstractThe role of the pituitary-adrenal axis in the inhibition of gastrointestinal transit caused by intrathecal administration of bombesin was examined. Bombesin (0.3-10 [mu]g) slowed transit by this route in a dose-related manner. Either hypophysectomy or adrenalectomy prevented the inhibition of gastrointestinal transit associated with bombesin (10 [mu]g, i.th.). The inhibitory gut effects of this peptide were not prevented in sham-operated rats. Intrathecal bombesin-induced inhibition of gastrointestinal transit is thus dependent upon an intact pituitary-adrenal axis.en_US
dc.format.extent319997 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleIntrathecal bombesin-induced inhibition of gastrointestinal transit: requirement for an intact pituitary-adrenal axisen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelChemistryen_US
dc.subject.hlbsecondlevelChemical Engineeringen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelEngineeringen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumUniversity of Michigan Medical School, Ann Arbor, MI 48109, U.S.A.en_US
dc.contributor.affiliationotherBristol-Myers Products, Hillside, NJ 07207, U.S.A.en_US
dc.contributor.affiliationotherTemple University School of Medicine, Philadelphia, PA 19140, U.S.A.en_US
dc.contributor.affiliationotherDepartment of Pharmacology, The University of Arizona Health Sciences Center, Tucson, AZ 85724, U.S.A.en_US
dc.identifier.pmid3755251en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/26176/1/0000255.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0167-0115(86)90006-6en_US
dc.identifier.sourceRegulatory Peptidesen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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