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Tumor necrosis factor stimulates interleukin-1 and prostaglandin E2 production in resting macrophages
dc.contributor.authorBachwich, Peter R.en_US
dc.contributor.authorChensue, Stephen W.en_US
dc.contributor.authorLarrick, James W.en_US
dc.contributor.authorKunkel, Steven L.en_US
dc.date.accessioned2006-04-07T19:31:57Z
dc.date.available2006-04-07T19:31:57Z
dc.date.issued1986-04-14en_US
dc.identifier.citationBachwich, P. R., Chensue, S. W., Larrick, J. W., Kunkel, S. L. (1986/04/14)."Tumor necrosis factor stimulates interleukin-1 and prostaglandin E2 production in resting macrophages." Biochemical and Biophysical Research Communications 136(1): 94-101. <http://hdl.handle.net/2027.42/26197>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WBK-4DXRY44-11F/2/7489a64958aabf3c1c6106149dd023f6en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/26197
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3486658&dopt=citationen_US
dc.description.abstractWe have investigated the effect of tumor necrosis factor on the release of interleukin-1 and PGE2 from murine resident peritoneal macrophages. Tumor necrosis factor causes an increase in the production of interleukin-1 and PGE2 with a maximum induction for both noted at 5.9 x 10-8M. While indomethacin decreased tumor necrosis factor induced PGE2 production, this cyclooxygenase inhibitor augmented tumor necrosis factor induced interleukin-1 production. Our data suggests that tumor necrosis factor may be an important immunopotentiating agent in addition to its previously described cytolytic and metabolic activities.en_US
dc.format.extent426161 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleTumor necrosis factor stimulates interleukin-1 and prostaglandin E2 production in resting macrophagesen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNatural Resources and Environmenten_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelEcology and Evolutionary Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pathology and Medicine University of Michigan Medical School, Ann Arbor, Michigan 48109, USAen_US
dc.contributor.affiliationumDepartment of Pathology and Medicine University of Michigan Medical School, Ann Arbor, Michigan 48109, USAen_US
dc.contributor.affiliationumDepartment of Pathology and Medicine University of Michigan Medical School, Ann Arbor, Michigan 48109, USAen_US
dc.contributor.affiliationotherCetus Immune Corporation, Palo Alto, California 94303, USAen_US
dc.identifier.pmid3486658en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/26197/1/0000276.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0006-291X(86)90881-8en_US
dc.identifier.sourceBiochemical and Biophysical Research Communicationsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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