Accelerated autoimmune disease and lymphoreticular neoplasms in F1 hybrid PN/NZB and NZB/PN mice
dc.contributor.author | Walker, Sara Ellen | en_US |
dc.contributor.author | Kier, Ann B. | en_US |
dc.contributor.author | Siegfied, Elaine C. | en_US |
dc.contributor.author | Harris, Bernadette G. | en_US |
dc.contributor.author | Schultz, Jane S. | en_US |
dc.date.accessioned | 2006-04-07T19:32:17Z | |
dc.date.available | 2006-04-07T19:32:17Z | |
dc.date.issued | 1986-04 | en_US |
dc.identifier.citation | Walker, Sara E., Kier, Ann B., Siegfied, Elaine C., Harris, Bernadette G., Schultz, Jane S. (1986/04)."Accelerated autoimmune disease and lymphoreticular neoplasms in F1 hybrid PN/NZB and NZB/PN mice." Clinical Immunology and Immunopathology 39(1): 81-92. <http://hdl.handle.net/2027.42/26206> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WCK-4BJW2F8-YW/2/79407001be76f5385dd10c5c544e8d94 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/26206 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3948438&dopt=citation | en_US |
dc.description.abstract | This report describes the first studies of inheritance of autoimmunity in inbred Palmerston North (PN) mice, a model of systemic lupus erythematosus (SLE). Mating of PN mice with the nonautoimmune DBA/2 strain produced evidence that PN disease had a recessive mode of inheritance. When PN mice were crossed with autoimmune NZB mice, female offspring from both crosses developed anti-DNA antibodies and died prematurely with vasculitis, renal disease, and lymphomas. In contrast, reciprocal hybrid males had different patterns of mortality; PN/NZB males from the PN female x NZB male mating had moderately prolonged life spans, whereas NZB/PN males from the opposite cross (NZB female x PN male) had prolonged survival to the mean age of 104 weeks. To determine if testicular hormones were solely responsible for increased longevity in hybrid males, PN/NZB and NZB/PN mice were castrated at 2 weeks of age and compared to sham-operated littermate controls. Prepubertal castration did not influence longevity in PN/NZB males, but loss of gonadal hormones significantly reduced life spans in reciprocal NZB/PN males. Female hybrids were not affected by oophorectomy. Because castration changed disease expression only in male hybrids from the NZB female x PN male cross, it was concluded that parentage influenced sensitivity to the protective effects of male hormones. Although surgical sterilization had disparate effects on males, castrated PN/NZB and NZB/PN males consistently outlived oophorectomized females. The lack of clear-cut reversal of disease in males subjected to early castration suggested that nonhormonal, possibly genetic, factors contributed to longevity in both groups of male hybrids. | en_US |
dc.format.extent | 936150 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Accelerated autoimmune disease and lymphoreticular neoplasms in F1 hybrid PN/NZB and NZB/PN mice | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Microbiology and Immunology | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan Medical School, Ann Arbor, Michigan, 48105, USA | en_US |
dc.contributor.affiliationother | Department of Medicine, College of Veterinary Medicine, University of Missouri, Columbia, Missouri 65201, USA; Rheumatology Section, Harry S. Truman Memorial Veterans Hospital, Columbia, Missouri 65201, USA | en_US |
dc.contributor.affiliationother | Veterinary Medical Diagnostic Laboratory, College of Veterinary Medicine, University of Missouri, Columbia, Missouri 65201, USA | en_US |
dc.contributor.affiliationother | Department of Medicine, College of Veterinary Medicine, University of Missouri, Columbia, Missouri 65201, USA | en_US |
dc.contributor.affiliationother | Department of Medicine, College of Veterinary Medicine, University of Missouri, Columbia, Missouri 65201, USA | en_US |
dc.identifier.pmid | 3948438 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/26206/1/0000286.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0090-1229(86)90207-2 | en_US |
dc.identifier.source | Clinical Immunology and Immunopathology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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