Nuclide imaging of vascular graft-platelet interactions: Comparison of indium excess and technetium subtraction techniques
dc.contributor.author | Wakefield, Thomas W. | en_US |
dc.contributor.author | Lindblad, Bengt | en_US |
dc.contributor.author | Graham, Linda M. | en_US |
dc.contributor.author | Whitehouse, Walter M. Jr. | en_US |
dc.contributor.author | Ripley, Shawn D. | en_US |
dc.contributor.author | Petry, Neil A. | en_US |
dc.contributor.author | Spaulding, Susan A. | en_US |
dc.contributor.author | Burkel, William E. | en_US |
dc.contributor.author | Stanley, James C. | en_US |
dc.date.accessioned | 2006-04-07T19:32:47Z | |
dc.date.available | 2006-04-07T19:32:47Z | |
dc.date.issued | 1986-04 | en_US |
dc.identifier.citation | Wakefield, Thomas W., Lindblad, Bengt, Graham, Linda M., Whitehouse, Jr., Walter M., Ripley, Shawn D., Petry, Neil A., Spaulding, Susan A., Burkel, William E., Stanley, James C. (1986/04)."Nuclide imaging of vascular graft-platelet interactions: Comparison of indium excess and technetium subtraction techniques." Journal of Surgical Research 40(4): 388-394. <http://hdl.handle.net/2027.42/26220> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WM6-4BNG1T4-74/2/d6b3aa6f28faec862dcf404005518c24 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/26220 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3517493&dopt=citation | en_US |
dc.description.abstract | Indium-111-labeled platelet adherence to ePTFE thoracoabdominal vascular prostheses in a canine model (n = 10) was quantitated by (1) an indium-111 excess technique, contrasting graft radioactivity to that in a reference region, and (2) a technetium-99m subtraction technique, with radioactivity of circulating platelets eliminated by discounting background blood activity. Variation in graft thrombogenicity was provided by seeding six prostheses with enzymatically derived autologous endothelial cells, and implanting four prostheses without seeding. Grafts were imaged at 1, 4, and 6 weeks postimplantation, with platelet labeling using indium-111-oxine and red blood cell labeling using technetium-99m. At 7 weeks grafts were excised and gamma activity was measured in proximal, middle, and distal segments. Luminal generation of TxB2 and 6-keto-PGF1[alpha] from midportions of grafts was assayed. Indium-111 excess ratios at 6 weeks correlated with actual gamma activity of excised grafts (proximal r = 0.80, P r = 0.73, P r = 0.48, ns) but such a correlation did not exist for the technetium-99m subtraction technique (r = -0.05, -0.25, and 0.16, in the three segments, respectively, all ns). The ratio of graft to aortic TxB2 production revealed a positive correlation with graft gamma activity (r = 0.87, P 1[alpha] to TxB2 production also correlated with gamma counts (r = -0.64, P = 0.05). In this experimental setting technetium-99m subtraction analysis was an imprecise method of detecting graft platelet accumulation, whereas indium-111 excess ratios proved to be a more accurate method of quantitating vascular prosthetic thrombogenicity. | en_US |
dc.format.extent | 895175 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Nuclide imaging of vascular graft-platelet interactions: Comparison of indium excess and technetium subtraction techniques | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Surgery and Anesthesiology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Surgery, Division of Peripheral Vascular Surgery, Ann Arbor, Michigan 48109, USA; Department of Medicine, Division of Nuclear Medicine, Ann Arbor, Michigan 48109, USA; Department of Anatomy and Cell Biology, Ann Arbor, Michigan 48109, USA; University of Michigan Medical School, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Department of Surgery, Division of Peripheral Vascular Surgery, Ann Arbor, Michigan 48109, USA; Department of Medicine, Division of Nuclear Medicine, Ann Arbor, Michigan 48109, USA; Department of Anatomy and Cell Biology, Ann Arbor, Michigan 48109, USA; University of Michigan Medical School, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Department of Surgery, Division of Peripheral Vascular Surgery, Ann Arbor, Michigan 48109, USA; Department of Medicine, Division of Nuclear Medicine, Ann Arbor, Michigan 48109, USA; Department of Anatomy and Cell Biology, Ann Arbor, Michigan 48109, USA; University of Michigan Medical School, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Department of Surgery, Division of Peripheral Vascular Surgery, Ann Arbor, Michigan 48109, USA; Department of Medicine, Division of Nuclear Medicine, Ann Arbor, Michigan 48109, USA; Department of Anatomy and Cell Biology, Ann Arbor, Michigan 48109, USA; University of Michigan Medical School, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Department of Surgery, Division of Peripheral Vascular Surgery, Ann Arbor, Michigan 48109, USA; Department of Medicine, Division of Nuclear Medicine, Ann Arbor, Michigan 48109, USA; Department of Anatomy and Cell Biology, Ann Arbor, Michigan 48109, USA; University of Michigan Medical School, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Department of Surgery, Division of Peripheral Vascular Surgery, Ann Arbor, Michigan 48109, USA; Department of Medicine, Division of Nuclear Medicine, Ann Arbor, Michigan 48109, USA; Department of Anatomy and Cell Biology, Ann Arbor, Michigan 48109, USA; University of Michigan Medical School, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Department of Surgery, Division of Peripheral Vascular Surgery, Ann Arbor, Michigan 48109, USA; Department of Medicine, Division of Nuclear Medicine, Ann Arbor, Michigan 48109, USA; Department of Anatomy and Cell Biology, Ann Arbor, Michigan 48109, USA; University of Michigan Medical School, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Department of Surgery, Division of Peripheral Vascular Surgery, Ann Arbor, Michigan 48109, USA; Department of Medicine, Division of Nuclear Medicine, Ann Arbor, Michigan 48109, USA; Department of Anatomy and Cell Biology, Ann Arbor, Michigan 48109, USA; University of Michigan Medical School, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Department of Surgery, Division of Peripheral Vascular Surgery, Ann Arbor, Michigan 48109, USA; Department of Medicine, Division of Nuclear Medicine, Ann Arbor, Michigan 48109, USA; Department of Anatomy and Cell Biology, Ann Arbor, Michigan 48109, USA; University of Michigan Medical School, Ann Arbor, Michigan 48109, USA | en_US |
dc.identifier.pmid | 3517493 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/26220/1/0000300.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0022-4804(86)90204-0 | en_US |
dc.identifier.source | Journal of Surgical Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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