Human placental Ca2+-ATPase: in vitro inhibition by DDT homologs
dc.contributor.author | Treinen, K. A. | en_US |
dc.contributor.author | Kulkarni, Arun P. | en_US |
dc.date.accessioned | 2006-04-07T19:33:49Z | |
dc.date.available | 2006-04-07T19:33:49Z | |
dc.date.issued | 1986-03 | en_US |
dc.identifier.citation | Treinen, K. A., Kulkarni, A. P. (1986/03)."Human placental Ca2+-ATPase: in vitro inhibition by DDT homologs." Toxicology Letters 30(3): 223-229. <http://hdl.handle.net/2027.42/26246> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6TCR-477XS8S-7K/2/2f28cabe0fb7eb31499242ff3077cf5f | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/26246 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2939596&dopt=citation | en_US |
dc.description.abstract | In vitro inhibition of Ca2+-ATPase by DDT homologs was studied using maternal brush-border membranes from human term placentas as an enzyme source. At 10 [mu]M concentration many of the compounds tested inhibited this enzyme. The order of effectiveness of inhibition was as follows: p,p'-DDE>p,p'-DDD>p,p'-DDT> methoxychlor(mec). Both p,p'-DDOH and p,p'-DDA did not inhibit the placental Ca2+-ATPase. Assays using varying concentrations (0.3 [mu]M to 0.1 mM) of p,p'-DDT were also performed. The inhibition of human placental Ca2+-ATPase ranged from 12% for 0.3 [mu]M p,p p,p'-DDT to 69% for 30 [mu]M p,p'-DDT. Higher concentrations of this pesticide failed to cause further enzyme inhibition. | en_US |
dc.format.extent | 500409 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Human placental Ca2+-ATPase: in vitro inhibition by DDT homologs | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Toxicology Program, Department of Environmental and Industrial Health, School of Public Health, University of Michigan, Ann Arbor, MI 48109-2029, U.S.A. | en_US |
dc.contributor.affiliationum | Toxicology Program, Department of Environmental and Industrial Health, School of Public Health, University of Michigan, Ann Arbor, MI 48109-2029, U.S.A. | en_US |
dc.identifier.pmid | 2939596 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/26246/1/0000326.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0378-4274(86)90159-1 | en_US |
dc.identifier.source | Toxicology Letters | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.