The influence of estrogen on nigrostriatal dopamine activity : Behavioral and neurochemical evidence for both pre- and postsynaptic components
dc.contributor.author | Becker, Jill B. | en_US |
dc.contributor.author | Beer, Mary E. | en_US |
dc.date.accessioned | 2006-04-07T19:36:35Z | |
dc.date.available | 2006-04-07T19:36:35Z | |
dc.date.issued | 1986-01 | en_US |
dc.identifier.citation | Becker, Jill B., Beer, Mary E. (1986/01)."The influence of estrogen on nigrostriatal dopamine activity : Behavioral and neurochemical evidence for both pre- and postsynaptic components." Behavioural Brain Research 19(1): 27-33. <http://hdl.handle.net/2027.42/26324> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6SYP-484NDFD-BW/2/24fce2aedc73b9f5a9ea772a318986c7 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/26324 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3954864&dopt=citation | en_US |
dc.description.abstract | The results of 3 experiments examining the influence of estrogen on the nigrostriatal dopamine (DA) system are reported. In two experiments the influence of hormonal manipulations on amphetamine (AMPH)-induced rotational behavior was investigated using rats with unilateral 6-hydroxydopamine lesions of the substantia nigra. It was found that: (1) female rats in estrus make more rotations than ovariectomized (OVX) rats; and (2) estrogen treatment (5 [mu]g estradiol benzoate, daily for 4 days) in OVX rats enhances AMPH-induced rotational behavior 4 h and 4 days after estrogen treatment. During the intervening period, at 24 h after cessation of estrogen treatment, control and hormone-treated animals did not differ. In a third experiment, the effect of estrogen treatment on the release of endogenous DA from striatal tissue slices in superfusion was examined. Estrogen enhanced AMPH-stimulated striatal DA release 4 h after the last treatment relative to OVX controls. However, 24 h and 4 days after estrogen treatment DA release had returned to control levels. It is suggested that estrogen has an immediate potentiating effect on striatal DA release, and this may be responsible for the increased behavioral response to AMPH 4 h after estrogen treatment. The previously demonstrated increase in postsynaptic striatal DA receptors may be responsible for the second increase in AMPH-induced rotational behavior, that occurs 4 days after estrogen treatment. | en_US |
dc.format.extent | 646668 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | The influence of estrogen on nigrostriatal dopamine activity : Behavioral and neurochemical evidence for both pre- and postsynaptic components | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Psychology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Social Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | The University of Michigan, Psychology Department, Ann Arbor, MI 48104-1687, U.S.A. | en_US |
dc.contributor.affiliationum | The University of Michigan, Psychology Department, Ann Arbor, MI 48104-1687, U.S.A. | en_US |
dc.identifier.pmid | 3954864 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/26324/1/0000411.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0166-4328(86)90044-6 | en_US |
dc.identifier.source | Behavioural Brain Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.