In-vivo studies on kappa opioid receptors
dc.contributor.author | Cowan, Alan | en_US |
dc.contributor.author | Gmerek, Debra E. | en_US |
dc.date.accessioned | 2006-04-07T19:37:03Z | |
dc.date.available | 2006-04-07T19:37:03Z | |
dc.date.issued | 1986 | en_US |
dc.identifier.citation | Cowan, Alan, Gmerek, Debra E. (1986)."In-vivo studies on kappa opioid receptors." Trends in Pharmacological Sciences 7(): 69-72. <http://hdl.handle.net/2027.42/26337> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T1K-48064GY-16/2/e513f25297f1f6f0938d7311f59f56f8 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/26337 | |
dc.description.abstract | The actions of opioids are mediated by multiple types of opioid receptor. As a result, `obtaining the right balance' is the catchphrase most frequently heard these days in analgesic research laboratories throughout the pharmaceutical industry. Tomorrow's analgesics will feature a prominent [kappa] component, a touch of [delta], a tickle of [mu], but not even a wisp of [sigma]. New compounds are fashioned largely from structure-activity relationships involving bioassays and radioligand receptor binding. These in-vitro approaches have become well established over the past decade since they help to link receptor type to the analgesic under investigation. What about the complementary preclinical tests in-vivo? Specifically, how can the animal pharmacologist assist in characterizing [kappa] opioid activity? In this article, Alan Cowan and Debra E. Gmerek present a survey of tests that are being used to detect and define [kappa] activity in-vivo. Special emphasis is placed on the rat bombesin-scratch test, a new procedure in which several [kappa]-preferring agents are selectively active. | en_US |
dc.format.extent | 493641 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | In-vivo studies on kappa opioid receptors | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationother | Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, USA | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/26337/1/0000424.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0165-6147(86)90257-9 | en_US |
dc.identifier.source | Trends in Pharmacological Sciences | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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