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Evaluation of plasma 3-methoxy-4-hydroxyphenylglycol
dc.contributor.authorHuber-Smith, Marla J.en_US
dc.contributor.authorNesse, Randolph M.en_US
dc.contributor.authorMazhar, M.en_US
dc.contributor.authorMcCann, Daisy S.en_US
dc.date.accessioned2006-04-07T19:37:23Z
dc.date.available2006-04-07T19:37:23Z
dc.date.issued1986en_US
dc.identifier.citationHuber-smith, M. J., Nesse, R., Mazhar, M., McCann, D. S. (1986)."Evaluation of plasma 3-methoxy-4-hydroxyphenylglycol." Journal of Chromatography B: Biomedical Sciences and Applications 377(): 91-99. <http://hdl.handle.net/2027.42/26347>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6TG9-44YS1PP-KV/2/1f9528027ace57ee3671d2ffd1917d27en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/26347
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3711248&dopt=citationen_US
dc.description.abstractA high-performance liquid chromatographic (HPLC) assay suitable for the evaluation of 3-methoxy-4-hydroxyphenylglycol (MHPG) in 1-ml aliquots of plasma is presented. Preparatory steps include extraction into ethyl acetate and minicolumn chromatography. Recoveries are monitored with [3H]MHPG. The HPLC procedure utilizes a C18 column, isocratic elution and amperometric detection. The assay was checked against a gas chromatographic--mass spectrometric procedure; the two procedures correlated well with a correlation coefficient of 0.99. Intra-assay reproducibility was 5.4%, inter-assay reproducibility 10.7%. Immediate changes in the orthostatic position did not affect the plasma MHPG concentration. Based on 22 normal controls the daytime plasma MHPG level was 2.98 +/- 0.66 ng/ml (mean +/- S.D.).en_US
dc.format.extent689867 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleEvaluation of plasma 3-methoxy-4-hydroxyphenylglycolen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelChemistryen_US
dc.subject.hlbsecondlevelChemical Engineeringen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelEngineeringen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumUniversity of Michigan Medical School, Ann Arbor, MI 48109 U.S.A.en_US
dc.contributor.affiliationumUniversity of Michigan Medical School, Ann Arbor, MI 48109 U.S.A.; University Medical Affiliates, P.C., 3139 S. Wayne Road, Wayne, MI 48184 U.S.A.en_US
dc.contributor.affiliationotherUniversity Medical Affiliates, P.C., 3139 S. Wayne Road, Wayne, MI 48184 U.S.A.en_US
dc.contributor.affiliationotherUniversity Medical Affiliates, P.C., 3139 S. Wayne Road, Wayne, MI 48184 U.S.A.en_US
dc.identifier.pmid3711248en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/26347/1/0000434.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/S0378-4347(00)80764-1en_US
dc.identifier.sourceJournal of Chromatography B: Biomedical Sciences and Applicationsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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