The capability for regulation of insulin secretion by somatostatin in purified pancreatic islet B cells during aging
dc.contributor.author | Magal, Ella | en_US |
dc.contributor.author | Chaudhuri, Minu | en_US |
dc.contributor.author | Adelman, Richard C. | en_US |
dc.date.accessioned | 2006-04-07T19:37:48Z | |
dc.date.available | 2006-04-07T19:37:48Z | |
dc.date.issued | 1986-01 | en_US |
dc.identifier.citation | Magal, Ella, Chaudhuri, Minu, Adelman, Richard C. (1986/01)."The capability for regulation of insulin secretion by somatostatin in purified pancreatic islet B cells during aging." Mechanisms of Ageing and Development 33(2): 139-146. <http://hdl.handle.net/2027.42/26358> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T31-47PG2F9-98/2/bbc34c4c812b2f5900f2b5cfdf6396de | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/26358 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2870220&dopt=citation | en_US |
dc.description.abstract | Pancreatic islet B cells from Sprague--Dawley and Fisher 344 rats aged 3-27 months were separated from A and D cells by centrifugation over a linear percoll density gradient, and incubated in vitro with various concentrations of glucose and somatostatin. Elevation of glucose concentration in the incubation medium from 2.6 to 16.7 mM provokes an insulin secretory response that is independent of rat donor age. Inhibition of the insulin secretory response by somatostatin is independent of rat donor age beyond 12 months. These data indicate that the impaired regulation of insulin secretion during aging observed previously in vivo and in vitro in intact islets may not be intrinsic to the B cells, but instead reflect changes in islet paracrine regulatory mechanisms that relate to the quality and/or quantity of endogenous somatostatin and/or glucagon. | en_US |
dc.format.extent | 388700 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | The capability for regulation of insulin secretion by somatostatin in purified pancreatic islet B cells during aging | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Geriatrics | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Institute of Gerontology and Department of Biological Chemistry, The University of Michigan, Ann Arbor, MI 48109-2007, U.S.A. | en_US |
dc.contributor.affiliationum | Institute of Gerontology and Department of Biological Chemistry, The University of Michigan, Ann Arbor, MI 48109-2007, U.S.A. | en_US |
dc.contributor.affiliationum | Institute of Gerontology and Department of Biological Chemistry, The University of Michigan, Ann Arbor, MI 48109-2007, U.S.A. | en_US |
dc.identifier.pmid | 2870220 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/26358/1/0000445.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0047-6374(86)90022-9 | en_US |
dc.identifier.source | Mechanisms of Ageing and Development | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.