Age effects in serial hypothalamic - pituitary - adrenal monitoring
dc.contributor.author | Greden, John F. | en_US |
dc.contributor.author | Flegel, Pamela | en_US |
dc.contributor.author | Haskett, Roger F. | en_US |
dc.contributor.author | Dilsaver, Steven C. | en_US |
dc.contributor.author | Carroll, Bernard J. | en_US |
dc.contributor.author | Grunhaus, Leon J. | en_US |
dc.contributor.author | Genero, Nancy | en_US |
dc.date.accessioned | 2006-04-07T19:38:10Z | |
dc.date.available | 2006-04-07T19:38:10Z | |
dc.date.issued | 1986 | en_US |
dc.identifier.citation | Greden, John F., Flegel, Pamela, Haskett, Roger, Dilsaver, Steven, Carroll, Bernard J., Grunhaus, Leon, Genero, Nancy (1986)."Age effects in serial hypothalamic - pituitary - adrenal monitoring." Psychoneuroendocrinology 11(2): 195-204. <http://hdl.handle.net/2027.42/26367> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6TBX-485YHMD-3W/2/cea25ff0cfc47a30fd68d4142098ae9d | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/26367 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3749402&dopt=citation | en_US |
dc.description.abstract | To evaluate age effects on hypothalamic - pituitary - adrenal (HPA) regulation in depressives, we studied 65 patients with major depressive disorder, endogenous subtype. With each patient serving as his or her own control, we compared weekly dexamethasone suppression test (DST) results among three age subgroups (N = 18; 40 - 70 years, N = 40; > 70 years, N = 7). The oldest patient group had higher mean post-dexamethasone plasma cortisol concentrations both before and after treatment, and more were DST nonsuppressors. Life table analyses revealed that elderly patients who were DST nonsuppressors had significantly slower patterns of normalization during treatment and that fewer elderly patients ever achieved normal suppression. The results indicate that age effects on HPA function may be confounded with other aspects of depression, such as severity, chronicity and number of previous episodes. | en_US |
dc.format.extent | 584637 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Age effects in serial hypothalamic - pituitary - adrenal monitoring | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Psychology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Social Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Clinical Studies Unit for Affective Disorders, Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Clinical Studies Unit for Affective Disorders, Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Clinical Studies Unit for Affective Disorders, Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Clinical Studies Unit for Affective Disorders, Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Clinical Studies Unit for Affective Disorders, Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Clinical Studies Unit for Affective Disorders, Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationother | Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, U.S.A. | en_US |
dc.identifier.pmid | 3749402 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/26367/1/0000454.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0306-4530(86)90054-5 | en_US |
dc.identifier.source | Psychoneuroendocrinology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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