Facilitation of lethal ventricular arrhythmias by therapeutic digoxin in conscious post infarction dogs
dc.contributor.author | Lynch, Joseph J. | en_US |
dc.contributor.author | Montgomery, Daniel G. | en_US |
dc.contributor.author | Lucchesi, Benedict Robert | en_US |
dc.date.accessioned | 2006-04-07T19:40:49Z | |
dc.date.available | 2006-04-07T19:40:49Z | |
dc.date.issued | 1986-05 | en_US |
dc.identifier.citation | Lynch, Joseph J., Montgomery, Daniel G., Lucchesi, Benedict R. (1986/05)."Facilitation of lethal ventricular arrhythmias by therapeutic digoxin in conscious post infarction dogs." American Heart Journal 111(5): 883-890. <http://hdl.handle.net/2027.42/26443> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6W9H-4BSVFX6-58/2/71db30996d0a303d0a6d60d6c3911633 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/26443 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3706108&dopt=citation | en_US |
dc.description.abstract | The proarrhythmic potential of digoxin, administered in a therapeutic dosage regimen, was evaluated in conscious dogs in the subacute phase of myocardial infarction. In this evaluation, digoxin (0.0125 mg/kg/day intravenously) or vehicle were administered to conscious dogs for periods of 5 to 7 days, commencing 4 to 5 days after anterior myocardial infarction. Before treatment, programmed ventricular stimulation failed to initiate ventricular tachycardia in 26 post infarction dogs. After treatment, programmed stimulation initiated ventricular tachyarrhythmias in only 1 of 13 digoxin-treated dogs (1.36 +/- 0.17 ng/ml serum digoxin) and in 0 of 13 vehicle-treated dogs. However, the incidences of early ventricular fibrilation (4 of 10 digoxin vs 0 of 12 vehicle; p p < 0.05) occurring in response to the development of posterolateral ischemia in the presence of previous anterior myocardial infarction was significantly greater in digoxin-treated (1.47 +/- 0.19 ng/ml serum digoxin) than in vehicle-treated animals. These findings suggest an enhanced susceptibility toward the development of ischemia-related lethal arrhythmias in the presence of therapeutic digoxin serum concentrations early after myocardial infarction, which is not predicted by programmed ventricular stimulation testing. | en_US |
dc.format.extent | 968985 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Facilitation of lethal ventricular arrhythmias by therapeutic digoxin in conscious post infarction dogs | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pharmacology, The University of Michigan Medical School, Ann Arbor, Mich., USA | en_US |
dc.contributor.affiliationum | Department of Pharmacology, The University of Michigan Medical School, Ann Arbor, Mich., USA | en_US |
dc.contributor.affiliationum | Department of Pharmacology, The University of Michigan Medical School, Ann Arbor, Mich., USA | en_US |
dc.identifier.pmid | 3706108 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/26443/1/0000531.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0002-8703(86)90638-1 | en_US |
dc.identifier.source | American Heart Journal | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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