Serial dexamethasone suppression tests in depressed patients treated only with electroconvulsive therapy
dc.contributor.author | Grunhaus, Leon J. | en_US |
dc.contributor.author | Zelnik, Thomas C. | en_US |
dc.contributor.author | Albala, A. Ariav | en_US |
dc.contributor.author | Rabin, David | en_US |
dc.contributor.author | Haskett, Roger F. | en_US |
dc.contributor.author | Zis, Athanasios P. | en_US |
dc.contributor.author | Greden, John F. | en_US |
dc.date.accessioned | 2006-04-07T19:46:24Z | |
dc.date.available | 2006-04-07T19:46:24Z | |
dc.date.issued | 1987 | en_US |
dc.identifier.citation | Grunhaus, Leon, Zelnik, Thomas, Albala, A. Ariav, Rabin, David, Haskett, Roger F., Zis, Athanasios P., Greden, John F. (1987)."Serial dexamethasone suppression tests in depressed patients treated only with electroconvulsive therapy." Journal of Affective Disorders 13(3): 233-240. <http://hdl.handle.net/2027.42/26519> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T2X-45XSPW5-6D/2/52d7ab42f02f86071494b00a20123c3b | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/26519 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2960715&dopt=citation | en_US |
dc.description.abstract | Several systematic studies have evaluated serial dexamethasone suppression tests (DST) in patients with major depression who were treated with antidepressant medications. DST changes were noted to parallel clinical improvement in most recovering patients. If serial DSTs are a valid state-related correlate of depressive pathophysiology, all types of effective antidepressant treatment should result in DST `normalization'. However, no treatment modalities other than antidepressant medications have been studied serially with systematic assessments. To test whether serial DSTs reflect clinical progress in depressives treated solely with electroconvulsive therapy (ECT), we studied weekly DSTs and Hamilton Rating Scales for Depression (HRSD) in 22 drug-free depressed patients. We observed progressive DST `normalization' in most patients and moderately high correlations between weekly DST and HRSD values throughout treatment. Most patients receiving ECT became DST suppressors. In most patients the DST appeared to reflect the severity of depressive pathophysiology, perhaps providing serial feedback to clinicians monitoring the progress of treatment with ECT. | en_US |
dc.format.extent | 631284 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Serial dexamethasone suppression tests in depressed patients treated only with electroconvulsive therapy | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Psychology | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbtoplevel | Social Sciences | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Clinical Studies Unit, Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Clinical Studies Unit, Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Clinical Studies Unit, Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Clinical Studies Unit, Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Clinical Studies Unit, Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Clinical Studies Unit, Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Clinical Studies Unit, Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.identifier.pmid | 2960715 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/26519/1/0000057.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0165-0327(87)90042-5 | en_US |
dc.identifier.source | Journal of Affective Disorders | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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