Relationship of the genes for Chediak-Higashi syndrome (beige) and the T-cell receptor [gamma] chain in mouse and man
dc.contributor.author | Holcombe, Randall F. | en_US |
dc.contributor.author | Strauss, William | en_US |
dc.contributor.author | Owen, Frances L. | en_US |
dc.contributor.author | Boxer, Laurence A. | en_US |
dc.contributor.author | Warren, Robert W. | en_US |
dc.contributor.author | Conley, Mary Ellen | en_US |
dc.contributor.author | Ferrara, James L. M. | en_US |
dc.contributor.author | Leavitt, Randi Y. | en_US |
dc.contributor.author | Fauci, Anthony S. | en_US |
dc.contributor.author | Taylor, Benjamin A. | en_US |
dc.contributor.author | Seidman, Jon G. | en_US |
dc.date.accessioned | 2006-04-07T19:46:26Z | |
dc.date.available | 2006-04-07T19:46:26Z | |
dc.date.issued | 1987-11 | en_US |
dc.identifier.citation | Holcombe, Randall F., Strauss, William, Owen, Frances L., Boxer, Laurence A., Warren, Robert W., Conley, Mary Ellen, Ferrara, James, Leavitt, Randi Y., Fauci, Anthony S., Taylor, Benjamin A., Seidman, J. G. (1987/11)."Relationship of the genes for Chediak-Higashi syndrome (beige) and the T-cell receptor [gamma] chain in mouse and man." Genomics 1(3): 287-291. <http://hdl.handle.net/2027.42/26520> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WG1-4DP5JGB-20/2/657b35e91762096ca441cb5ec1dd2f36 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/26520 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2895730&dopt=citation | en_US |
dc.description.abstract | The genetic linkage of Chediak-Higashi syndrome and its murine analog, beige (bg), to the T-cell receptor (TCR-[gamma]) [gamma] chain gene is further defined. Previous studies using recombinant inbred strains of mice demonstrated that the murine bg gene is genetically linked to a murine TCR-[gamma] gene. We report that in the mouse the frequency of recombination between these two markers is 0.025. Further, we tested the hypothesis that these two genes are linked in the human genome by analyzing restriction fragment length polymorphisms (RFLPs) in five families with children afflicted with Chediak-Higashi syndrome. In three families, RFLPs in TCR-[gamma] genes were inherited discordantly from Chediak-Higashi syndrome, demonstrating nonlinkage. We postulate that there is an evolutionary chromosomal breakpoint between the bg gene and the TCR-[gamma] gene. | en_US |
dc.format.extent | 1089010 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Relationship of the genes for Chediak-Higashi syndrome (beige) and the T-cell receptor [gamma] chain in mouse and man | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Division of Pediatric Hematology/Oncology, Mott Hospital, University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationother | Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA | en_US |
dc.contributor.affiliationother | Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA | en_US |
dc.contributor.affiliationother | Department of Pathology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA | en_US |
dc.contributor.affiliationother | Division of Rheumatology and Immunology, Department of Pediatrics, University of North Carolina, Chapel Hill, North Carolina 27599, USA | en_US |
dc.contributor.affiliationother | Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA | en_US |
dc.contributor.affiliationother | Division of Hematology/Oncology, Children's Hospital Medical Center, Boston, Massachusetts 02115, USA | en_US |
dc.contributor.affiliationother | NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA | en_US |
dc.contributor.affiliationother | NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA | en_US |
dc.contributor.affiliationother | The Jackson Laboratory, Bar Harbor, Maine 04609, USA | en_US |
dc.contributor.affiliationother | Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA | en_US |
dc.identifier.pmid | 2895730 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/26520/1/0000058.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0888-7543(87)90058-9 | en_US |
dc.identifier.source | Genomics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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