Identification and characterization of a human transthyretin variant
dc.contributor.author | Strahler, John R. | en_US |
dc.contributor.author | Rosenblum, Barnett B. | en_US |
dc.contributor.author | Hanash, Samir M. | en_US |
dc.date.accessioned | 2006-04-07T19:47:10Z | |
dc.date.available | 2006-04-07T19:47:10Z | |
dc.date.issued | 1987-10-14 | en_US |
dc.identifier.citation | Strahler, John R., Rosenblum, Barnett B., Hanash, Samir M. (1987/10/14)."Identification and characterization of a human transthyretin variant." Biochemical and Biophysical Research Communications 148(1): 471-477. <http://hdl.handle.net/2027.42/26538> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WBK-4DMX8G3-R7/2/30814696076c9a67154a98b2122aee67 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/26538 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3675594&dopt=citation | en_US |
dc.description.abstract | An apparent Mr variant of plasma transthyretin (TTR), previously detected using 2-D PAGE, is the first reported occurrence of this type of human TTR variant. We characterized the variant TTR to determine the nature of this difference. Comparative tryptic peptide maps of variant and normal TTR and sequencing of peptides which differed indicated the variant contained a single amino acid substitution of valine for tyrosine at position 116. Because such a change requires two nucleotide substitutions, we postulate the variant arose through mutation in codon 116 of a heretofore unrecognized polymorphic or rare variant allele of TTR. | en_US |
dc.format.extent | 585197 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Identification and characterization of a human transthyretin variant | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Department of Pediatrics, University of Illinois, College of Medicine at Chicago, Chicago, Illinois 60612, USA; Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA. | en_US |
dc.contributor.affiliationum | Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA | en_US |
dc.identifier.pmid | 3675594 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/26538/1/0000077.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0006-291X(87)91135-1 | en_US |
dc.identifier.source | Biochemical and Biophysical Research Communications | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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