Protamine reversal of anticoagulation achieved with a low molecular weight heparin. The effects on eicosanoids, clotting and complement factors
dc.contributor.author | Lindblad, Bengt | en_US |
dc.contributor.author | Borgstrom, Anders | en_US |
dc.contributor.author | Wakefield, Thomas W. | en_US |
dc.contributor.author | Whitehouse, Walter M. Jr. | en_US |
dc.contributor.author | Stanley, James C. | en_US |
dc.date.accessioned | 2006-04-07T19:47:25Z | |
dc.date.available | 2006-04-07T19:47:25Z | |
dc.date.issued | 1987-10-01 | en_US |
dc.identifier.citation | Lindblad, Bengt, Borgstrom, Anders, Wakefield, Thomas W., Whitehouse, Jr., Walter M., Stanley, James C. (1987/10/01)."Protamine reversal of anticoagulation achieved with a low molecular weight heparin. The effects on eicosanoids, clotting and complement factors." Thrombosis Research 48(1): 31-40. <http://hdl.handle.net/2027.42/26544> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T1C-4C2SFCP-26/2/d120579576bce1d7c71f8f6ed758ef2a | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/26544 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2827339&dopt=citation | en_US |
dc.description.abstract | Hemodynamic and hematologic effects of protamine reversal of low molecular weight heparin (LMWH) anticoagulation with and without protamine pretreatment, as well as reversal of anticoagulation with unfractionated standard heparin (SH), were studied in canine subjects. Protamine reversal caused less severe thrombocytopenia in the two LMWH groups compared to SH animals, while neutropenia occurred equally in all groups. Cl-esterase inhibitor levels were minimally increased, whereas C3 levels and leucotriene levels were unaltered. TxB2 and 6-keto-PGF1[alpha] increased during protamine reversal of LMWH anticoagulation. TCT and APTT were affected less with LMWH than SH anticoagulation. Anti-Xa levels increased with anticoagulation in all animals, but protamine did not reverse the elevated anti-Xa levels in LMWH anticoagulated dogs to the same degree as occurred with SH anticoagulation. TCT, APTT and bleeding times were normalized by protamine in all animals. Protamine reversal of LMWH anticoagulation with or without protamine pretreatment did not reveal any clear differences in eicosanoids or complement factors compared to SH anticoagulation, although differences in anti-Xa activity clearly separated these two heparins. | en_US |
dc.format.extent | 664938 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Protamine reversal of anticoagulation achieved with a low molecular weight heparin. The effects on eicosanoids, clotting and complement factors | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Division of Peripheral Vascular Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Division of Peripheral Vascular Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Division of Peripheral Vascular Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Division of Peripheral Vascular Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Division of Peripheral Vascular Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA | en_US |
dc.identifier.pmid | 2827339 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/26544/1/0000083.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0049-3848(87)90343-4 | en_US |
dc.identifier.source | Thrombosis Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.