Biochemical systems theory and metabolic control theory: 1. fundamental similarities and differences
dc.contributor.author | Savageau, Michael A. | en_US |
dc.contributor.author | Voit, Eberhard O. | en_US |
dc.contributor.author | Irvine, Douglas H. | en_US |
dc.date.accessioned | 2006-04-07T19:47:37Z | |
dc.date.available | 2006-04-07T19:47:37Z | |
dc.date.issued | 1987-10 | en_US |
dc.identifier.citation | Savageau, Michael A., Voit, Eberhard O., Irvine, Douglas H. (1987/10)."Biochemical systems theory and metabolic control theory: 1. fundamental similarities and differences." Mathematical Biosciences 86(2): 127-145. <http://hdl.handle.net/2027.42/26550> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6VHX-45DHJW1-1/2/ed4dd9c81d37cd9e09e5fdfc9ef355d5 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/26550 | |
dc.description.abstract | Biochemical Systems Theory (BST) was developed in the late 1960s to explicate the integrated behavior of intact biochemical systems--specific dynamic behavior as well as general principles of design--in relation to the properties of their underlying molecular elements. This approach was used successfully in a number of biochemical and other biological applications throughout the 1970s and 1980s. A related approach, Metabolic Control Theory (MCT), was proposed in the mid 1970s. Its developments generally have followed without reference the analogous developments in BST, and its proponents have treated the two approaches as if they were unrelated. Detailed comparison of the fundamental structures of BST and MCT shows that, although there are some superficial differences, both in fact are based upon the same underlying formalism. Molecular descriptions in MCT comprise a special case of those in BST. Systemic descriptions differ with respect to the level of aggregation assumed. The aggregation at the level of net increase or net decrease of each system constituent found in BST is shown to produce the more revealing and useful theory, and results presented elsewhere [41] suggest that this level of aggregation also provides a more accurate description of the system. At this fundamental level, MCT represents a special case of BST, for the content and range of validity of BST are more inclusive than those of MCT. | en_US |
dc.format.extent | 1311076 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Biochemical systems theory and metabolic control theory: 1. fundamental similarities and differences | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Statistics and Numeric Data | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Mathematics | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Social Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Microbiology and Immunology, The University of Michigan, Ann Arbor, Michigan 48109 USA | en_US |
dc.contributor.affiliationum | Department of Microbiology and Immunology, The University of Michigan, Ann Arbor, Michigan 48109 USA | en_US |
dc.contributor.affiliationum | Department of Microbiology and Immunology, The University of Michigan, Ann Arbor, Michigan 48109 USA | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/26550/1/0000089.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0025-5564(87)90007-1 | en_US |
dc.identifier.source | Mathematical Biosciences | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.