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Extracellular calcium alters frequency modulation of [3H]acetylcholine release from rat hippocampal slices

dc.contributor.authorPohorecki, Romanen_US
dc.contributor.authorFrench, Jonathanen_US
dc.contributor.authorDomino, Edward F.en_US
dc.date.accessioned2006-04-07T19:48:39Z
dc.date.available2006-04-07T19:48:39Z
dc.date.issued1987-09-08en_US
dc.identifier.citationPohorecki, Roman, French, Jonathan, Domino, Edward F. (1987/09/08)."Extracellular calcium alters frequency modulation of [3H]acetylcholine release from rat hippocampal slices." Brain Research 420(1): 199-203. <http://hdl.handle.net/2027.42/26578>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6SYR-4836162-296/2/f92a24142d20c2c2076e0bc38f405648en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/26578
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2445430&dopt=citationen_US
dc.description.abstractThe concentration of extracellular Ca2+ has been shown to enhance or attenuate [3H]acetylcholine (ACh) release subsequent to a conditioning stimulus in rat brain hippocampal slices. Slices were incubated in vitro in [3H]choline solution. Subsequently the slices were subjected to two consecutive electrical stimulations separated by 15 or 30 min at 0.25, 1, 4 and 16 Hz and [3H]ACh release was assessed. It was found that a conditioning stimulus may reduce [3H]ACh release during a second stimulation. This phenomenon is frequency related and disappears when the two stimulations are 30 min apart. High extracellular Ca2+ (4.0 mM) further attenuated [3H]ACh release during the second stimulation whereas low Ca2+ (0.32 mM) abolished the decrease in [3H]ACh release following the second stimulation in all frequencies tested.en_US
dc.format.extent363525 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleExtracellular calcium alters frequency modulation of [3H]acetylcholine release from rat hippocampal slicesen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pharmacology, University of Michigan, Ann Arbor, MI 48109-0626, U.S.A.en_US
dc.contributor.affiliationumDepartment of Pharmacology, University of Michigan, Ann Arbor, MI 48109-0626, U.S.A.en_US
dc.contributor.affiliationumDepartment of Pharmacology, University of Michigan, Ann Arbor, MI 48109-0626, U.S.A.en_US
dc.identifier.pmid2445430en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/26578/1/0000117.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0006-8993(87)90261-7en_US
dc.identifier.sourceBrain Researchen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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