Extracellular calcium alters frequency modulation of [3H]acetylcholine release from rat hippocampal slices
dc.contributor.author | Pohorecki, Roman | en_US |
dc.contributor.author | French, Jonathan | en_US |
dc.contributor.author | Domino, Edward F. | en_US |
dc.date.accessioned | 2006-04-07T19:48:39Z | |
dc.date.available | 2006-04-07T19:48:39Z | |
dc.date.issued | 1987-09-08 | en_US |
dc.identifier.citation | Pohorecki, Roman, French, Jonathan, Domino, Edward F. (1987/09/08)."Extracellular calcium alters frequency modulation of [3H]acetylcholine release from rat hippocampal slices." Brain Research 420(1): 199-203. <http://hdl.handle.net/2027.42/26578> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6SYR-4836162-296/2/f92a24142d20c2c2076e0bc38f405648 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/26578 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2445430&dopt=citation | en_US |
dc.description.abstract | The concentration of extracellular Ca2+ has been shown to enhance or attenuate [3H]acetylcholine (ACh) release subsequent to a conditioning stimulus in rat brain hippocampal slices. Slices were incubated in vitro in [3H]choline solution. Subsequently the slices were subjected to two consecutive electrical stimulations separated by 15 or 30 min at 0.25, 1, 4 and 16 Hz and [3H]ACh release was assessed. It was found that a conditioning stimulus may reduce [3H]ACh release during a second stimulation. This phenomenon is frequency related and disappears when the two stimulations are 30 min apart. High extracellular Ca2+ (4.0 mM) further attenuated [3H]ACh release during the second stimulation whereas low Ca2+ (0.32 mM) abolished the decrease in [3H]ACh release following the second stimulation in all frequencies tested. | en_US |
dc.format.extent | 363525 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Extracellular calcium alters frequency modulation of [3H]acetylcholine release from rat hippocampal slices | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109-0626, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109-0626, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109-0626, U.S.A. | en_US |
dc.identifier.pmid | 2445430 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/26578/1/0000117.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0006-8993(87)90261-7 | en_US |
dc.identifier.source | Brain Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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