[D-Ala2,(F5)Phe4]-dynorphin1-13-NH2 (DAFPHEDYN): A potent analog of dynorphin 1-13
dc.contributor.author | Michael Walker, J. | en_US |
dc.contributor.author | Coy, David H. | en_US |
dc.contributor.author | Young, Elizabeth A. | en_US |
dc.contributor.author | Baldrighi, Giulio | en_US |
dc.contributor.author | Siegel, Stephen F. | en_US |
dc.contributor.author | Bowen, Wayne D. | en_US |
dc.contributor.author | Akil, Huda | en_US |
dc.date.accessioned | 2006-04-07T19:49:24Z | |
dc.date.available | 2006-04-07T19:49:24Z | |
dc.date.issued | 1987 | en_US |
dc.identifier.citation | Michael Walker, J., Coy, David H., Young, Elizabeth A., Baldrighi, Giulio, Siegel, Stephen F., Bowen, Wayne D., Akil, Huda (1987)."[D-Ala2,(F5)Phe4]-dynorphin1-13-NH2 (DAFPHEDYN): A potent analog of dynorphin 1-13." Peptides 8(5): 811-817. <http://hdl.handle.net/2027.42/26600> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T0M-47T8WGT-HN/2/4d91027a512dfaf6d234dc682c24849e | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/26600 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2893357&dopt=citation | en_US |
dc.description.abstract | Intracerebroventricular administration of the dynorphin analog, [D-Ala2,(F5)Phe4]-dynorphin1-13-NH2 (DAFPHEDYN) in rats produced diuresis and profound analgesia. Both effects were antagonized by central administration of naltrexone or naloxone. Intravenous administration of 10, 25, and 50 mg/kg of DAFPHEDYN failed to induce diuresis. The increased potency of DAFPHEDYN was apparent from the failure of an equal dose of the parent compound (dynorphin 1-13) to produce diuresis and the failure of [D-Ala2]-dynorphin1-13-NH2 to produce analgesia. Radioligand binding studies indicated the DAFPHEDYN retains the same degree of [kappa] selectivity as the parent compound (dynorphin 1-13) though a drop in affinity occurred. DAFPHEDYN may be of significant interest because it retains the essential pharmacology of the parent compound and exhibits marked in vivo potency. | en_US |
dc.format.extent | 658803 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | [D-Ala2,(F5)Phe4]-dynorphin1-13-NH2 (DAFPHEDYN): A potent analog of dynorphin 1-13 | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Mental Health Research Institute, University of Michigan, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Mental Health Research Institute, University of Michigan, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Mental Health Research Institute, University of Michigan, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationother | Department of Psychology and Division of Biology and Medicine Brown University, Providence, RI 02912, USA | en_US |
dc.contributor.affiliationother | Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70196, USA | en_US |
dc.contributor.affiliationother | Department of Psychology and Division of Biology and Medicine Brown University, Providence, RI 02912, USA | en_US |
dc.contributor.affiliationother | Department of Psychology and Division of Biology and Medicine Brown University, Providence, RI 02912, USA | en_US |
dc.identifier.pmid | 2893357 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/26600/1/0000141.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0196-9781(87)90064-7 | en_US |
dc.identifier.source | Peptides | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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