Show simple item record

[D-Ala2,(F5)Phe4]-dynorphin1-13-NH2 (DAFPHEDYN): A potent analog of dynorphin 1-13

dc.contributor.authorMichael Walker, J.en_US
dc.contributor.authorCoy, David H.en_US
dc.contributor.authorYoung, Elizabeth A.en_US
dc.contributor.authorBaldrighi, Giulioen_US
dc.contributor.authorSiegel, Stephen F.en_US
dc.contributor.authorBowen, Wayne D.en_US
dc.contributor.authorAkil, Hudaen_US
dc.date.accessioned2006-04-07T19:49:24Z
dc.date.available2006-04-07T19:49:24Z
dc.date.issued1987en_US
dc.identifier.citationMichael Walker, J., Coy, David H., Young, Elizabeth A., Baldrighi, Giulio, Siegel, Stephen F., Bowen, Wayne D., Akil, Huda (1987)."[D-Ala2,(F5)Phe4]-dynorphin1-13-NH2 (DAFPHEDYN): A potent analog of dynorphin 1-13." Peptides 8(5): 811-817. <http://hdl.handle.net/2027.42/26600>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T0M-47T8WGT-HN/2/4d91027a512dfaf6d234dc682c24849een_US
dc.identifier.urihttps://hdl.handle.net/2027.42/26600
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2893357&dopt=citationen_US
dc.description.abstractIntracerebroventricular administration of the dynorphin analog, [D-Ala2,(F5)Phe4]-dynorphin1-13-NH2 (DAFPHEDYN) in rats produced diuresis and profound analgesia. Both effects were antagonized by central administration of naltrexone or naloxone. Intravenous administration of 10, 25, and 50 mg/kg of DAFPHEDYN failed to induce diuresis. The increased potency of DAFPHEDYN was apparent from the failure of an equal dose of the parent compound (dynorphin 1-13) to produce diuresis and the failure of [D-Ala2]-dynorphin1-13-NH2 to produce analgesia. Radioligand binding studies indicated the DAFPHEDYN retains the same degree of [kappa] selectivity as the parent compound (dynorphin 1-13) though a drop in affinity occurred. DAFPHEDYN may be of significant interest because it retains the essential pharmacology of the parent compound and exhibits marked in vivo potency.en_US
dc.format.extent658803 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.title[D-Ala2,(F5)Phe4]-dynorphin1-13-NH2 (DAFPHEDYN): A potent analog of dynorphin 1-13en_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbsecondlevelChemistryen_US
dc.subject.hlbsecondlevelChemical Engineeringen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelEngineeringen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumMental Health Research Institute, University of Michigan, Ann Arbor, MI 48109, USAen_US
dc.contributor.affiliationumMental Health Research Institute, University of Michigan, Ann Arbor, MI 48109, USAen_US
dc.contributor.affiliationumMental Health Research Institute, University of Michigan, Ann Arbor, MI 48109, USAen_US
dc.contributor.affiliationotherDepartment of Psychology and Division of Biology and Medicine Brown University, Providence, RI 02912, USAen_US
dc.contributor.affiliationotherDepartment of Medicine, Tulane University School of Medicine, New Orleans, LA 70196, USAen_US
dc.contributor.affiliationotherDepartment of Psychology and Division of Biology and Medicine Brown University, Providence, RI 02912, USAen_US
dc.contributor.affiliationotherDepartment of Psychology and Division of Biology and Medicine Brown University, Providence, RI 02912, USAen_US
dc.identifier.pmid2893357en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/26600/1/0000141.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0196-9781(87)90064-7en_US
dc.identifier.sourcePeptidesen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.