Excitatory amino acid antagonists induce a phencyclidine-like catalepsy in pigeons: Structure-activity studies
dc.contributor.author | Koek, Wouter | en_US |
dc.contributor.author | Woods, James H. | en_US |
dc.contributor.author | Mattson, M. V. | en_US |
dc.contributor.author | Jacobson, Arthur E. | en_US |
dc.contributor.author | Mudar, Pamela J. | en_US |
dc.date.accessioned | 2006-04-07T19:49:33Z | |
dc.date.available | 2006-04-07T19:49:33Z | |
dc.date.issued | 1987-09 | en_US |
dc.identifier.citation | Koek, W., Woods, J. H., Mattson, M. V., Jacobson, A. E., Mudar, P. J. (1987/09)."Excitatory amino acid antagonists induce a phencyclidine-like catalepsy in pigeons: Structure-activity studies." Neuropharmacology 26(9): 1261-1265. <http://hdl.handle.net/2027.42/26604> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T0C-479DGFM-8J/2/e36d287d6f4f09c364f71519c3f2771a | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/26604 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3670555&dopt=citation | en_US |
dc.description.abstract | The excitatory amino acid antagonists -2-amino-5-phosphonovalerate (-AP5), its isomers -(-)-AP5 and -(+)-AP5, -2-amino-4-phosphonobutyrate (AP4), -2-amino-7-phosphonoheptanoate (AP7), [beta]--aspartylaminomethylphosphonic acid (ASP-AMP), cis-2,3-piperidinedi-carboxylic acid (cis-PDA), and [gamma]--glutamylaminomethylsulphonic acid (GAMS) were tested for their ability to produce a phencyclidine (PCP)-like catalepsy in pigeons when administered intracerebro-ventricularly. Each of the antagonists produced catalepsy, although -AP5, and the non-selective antagonists GAMS and cis-PDA, produced the effect only at toxic doses. The rank order of potency to produce catalepsy was AP7 > -AP5 > -AP5 > cis-pda > ASP-AMP > AP4 > -AP5 > GAMS; there was a strong positive correlation between this rank order of potency vivo and the potency order of these compounds in vitro as NMDA antagonists. The antagonists did not displace significant amounts of [3H]N[1-(2-thienyl)cyclohexyl]piperidine (a congener of phencyclidine) from its recognition site in the brain of pigeon. Thus, the PCP-like catalepsy that is produced by the excitatory neurotransmission at NMDA-preferring receptors that are distinct from, but related to, PCP receptors. The results strongly support the hypothesis that a reduction of neurotransmission at excitatory synapses, utilizing NMDA-preferring receptors, may underlie catalepsy in pigeons induced by PCP. | en_US |
dc.format.extent | 516289 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Excitatory amino acid antagonists induce a phencyclidine-like catalepsy in pigeons: Structure-activity studies | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Departments of Pharmacology, University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Departments of Psychology, Training Program, University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Departments of Neuroscience Training Program, University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Departments of Neuroscience Training Program, University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationother | Laboratory of Chemistry, NIDDK, National Institutes of Health, Bethesda, MD 20892, U.S.A. | en_US |
dc.identifier.pmid | 3670555 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/26604/1/0000145.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0028-3908(87)90085-2 | en_US |
dc.identifier.source | Neuropharmacology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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