Apolipoprotein E polymorphism and plasma cholesterol response to probucol
dc.contributor.author | Nestruck, A. Christine | en_US |
dc.contributor.author | Bouthillier, Daniel | en_US |
dc.contributor.author | Sing, Charles F. | en_US |
dc.contributor.author | Davignon, Jean | en_US |
dc.date.accessioned | 2006-04-07T19:50:34Z | |
dc.date.available | 2006-04-07T19:50:34Z | |
dc.date.issued | 1987-08 | en_US |
dc.identifier.citation | Nestruck, A. Christine, Bouthillier, Daniel, Sing, Charles F., Davignon, Jean (1987/08)."Apolipoprotein E polymorphism and plasma cholesterol response to probucol." Metabolism 36(8): 743-747. <http://hdl.handle.net/2027.42/26631> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WN4-4C2S8F0-DP/2/a0666b7fdebb7bd842d111bfcdbb175e | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/26631 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3600286&dopt=citation | en_US |
dc.description.abstract | Probucol has been shown to be an effective and well-tolerated cholesterol-lowering drug. However, response in terms of cholesterol reduction has been shown to vary significantly among individuals. The purpose of this study was to assess the role of apolipoprotein E polymorphism in determining this variation. A retrospective study of 89 hypercholesterolemic type II patients who had been treated with probucol (1 g/d) and for whom the apolipoprotein E phenotype was known was carried out. The patients were first grouped into those with heterozygous familial hypercholesterolemia (FH) and those considered to have other forms of hypercholesterolemia (non-FH). Further subclassification of the individuals in both groups as IIa or IIb, allowed the definition of four diagnostic classes, FH IIa or IIb and non-FH IIa or IIb. Among these classes there was no significant heterogeneity for the relationship between response and age or sex. After correction for between-class heterogeneity in duration of probucol treatment, comparison of individuals with the apo E3/3 phenotype with those carrying the [epsilon]4 allele showed significant differences in cholesterol reduction both absolute change and percent change. Further contrasts between diagnostic and apo E genotype stratifications of these data showed that the FH patients carrying the [epsilon]4 allele had the greatest reduction in cholesterol level. | en_US |
dc.format.extent | 689080 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Apolipoprotein E polymorphism and plasma cholesterol response to probucol | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Medicine (General) | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Lipid Metabolism and Atherosclerosis Research, Clinical Research Institute of Montreal, Canada; Department of Human Genetics, University of Michigan, USA. | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan, USA; Department of Lipid Metabolism and Atherosclerosis Research, Clinical Research Institute of Montreal, Canada. | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan, USA; Department of Lipid Metabolism and Atherosclerosis Research, Clinical Research Institute of Montreal, Canada. | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan, USA; Department of Lipid Metabolism and Atherosclerosis Research, Clinical Research Institute of Montreal, Canada. | en_US |
dc.identifier.pmid | 3600286 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/26631/1/0000172.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0026-0495(87)90110-7 | en_US |
dc.identifier.source | Metabolism | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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