Hypoxia-ischemia produces focal disruption of glutamate receptors in developing brain
dc.contributor.author | Silverstein, Faye Sarah | en_US |
dc.contributor.author | Torke, Lynn | en_US |
dc.contributor.author | Barks, John D.E. | en_US |
dc.contributor.author | Johnston, Michael V. | en_US |
dc.date.accessioned | 2006-04-07T19:51:05Z | |
dc.date.available | 2006-04-07T19:51:05Z | |
dc.date.issued | 1987-07 | en_US |
dc.identifier.citation | Silverstein, Faye S., Torke, Lynn, Barks, John, Johnston, Michael V. (1987/07)."Hypoxia-ischemia produces focal disruption of glutamate receptors in developing brain." Developmental Brain Research 34(1): 33-39. <http://hdl.handle.net/2027.42/26646> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6SYW-484DGPC-50/2/f9514e95cfa0ad2fb9e23bd0042415b6 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/26646 | |
dc.description.abstract | We examined the impact of a perinatal hypoxic-ischemic insult on the distribution of glutamate receptors in developing brain. We used a well characterized rodent model for perinatal hypoxic-ischemic encephalopathy, unilateral carotid artery occlusion followed by exposure to 8% oxygen for 2.5 h in 7-day-old rat pups. This preparation results in focal neuronal damage in striatum, hippocampus, and cortex ipsilateral to ligation. Alterations in the regional distribution of glutamate binding in the first 24 h after the insult were assessed with quantitative in vitro [3H]glutamate autoradiography. In lesioned animals, we found progressive selective reductions in [3H]glutamate binding in forebrain ipsilateral to ligation in regions destined for neuronal damage. The earliest and most prominent unilateral reductions in binding were noted in the dentate gyrus of hippocampus (-45 +/- 9%, compared with contralateral hemisphere at 24 h). Acute reductions in specific glutamate binding appear to be a sensitive marker for hypoxic-ischemic neuronal damage in the immature brain. These observations suggest that neurons bearing glutamate receptors may be particularly susceptible to hypoxic-ischemic injury. | en_US |
dc.format.extent | 796005 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Hypoxia-ischemia produces focal disruption of glutamate receptors in developing brain | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Psychology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Social Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Departments of Pediatrics and Neurology, University of Michigan Medical School, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Departments of Pediatrics and Neurology, University of Michigan Medical School, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Departments of Pediatrics and Neurology, University of Michigan Medical School, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Center for Human Growth and Development, University of Michigan, Ann Arbor, MI, U.S.A.; Departments of Pediatrics and Neurology, University of Michigan Medical School, Ann Arbor, MI, USA. | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/26646/1/0000188.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0165-3806(87)90192-1 | en_US |
dc.identifier.source | Developmental Brain Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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