The effects of footshock stress on regional brain dopamine metabolism and pituitary [beta]-endorphin release in rats previously sensitized to amphetamine
dc.contributor.author | Robinson, Terry E. | en_US |
dc.contributor.author | Becker, Jill B. | en_US |
dc.contributor.author | Young, Elizabeth A. | en_US |
dc.contributor.author | Akil, Huda | en_US |
dc.contributor.author | Castaneda, Edward | en_US |
dc.date.accessioned | 2006-04-07T19:51:55Z | |
dc.date.available | 2006-04-07T19:51:55Z | |
dc.date.issued | 1987-07 | en_US |
dc.identifier.citation | Robinson, T. E., Becker, Jill B., Young, Elizabeth A., Akil, Huda, Castaneda, E. (1987/07)."The effects of footshock stress on regional brain dopamine metabolism and pituitary [beta]-endorphin release in rats previously sensitized to amphetamine." Neuropharmacology 26(7, Part 1): 679-691. <http://hdl.handle.net/2027.42/26668> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T0C-475J31B-5/2/2f6fc41d7d993ae981242efe1fa5fd5b | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/26668 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2957606&dopt=citation | en_US |
dc.description.abstract | The repeated intermittent administration of amphetamine (AMP) produces an enduring enhancement in the response of dopamine (DA) systems in the brain to a subsequent "challenge" with amphetamine. However, former amphetamine addicts are not only hypersensitive to amphetamine, but also to "physical or psychologtical stress". This suggests that sensitization to amphetamine may change the response of DA neurons in brain to subsequent stress. To explore this idea, the effects of footshock stress on regional metabolism of DA in brain, and on the concentrations of plasma [beta]-endorphin and N-acetylated [beta]-endorphin, were studied in rats previously exposed to amphetamine or saline. It was found that: (I) Prior treatment with amphetamine produced enduring (at least 7 days) changes in the dopaminergic response to footshock in the medial frontal cortex, hypothalamus, dorsolateral striatum and nucleus accumbens. Generally, rats pretreated with amphetamine showed a greater initial reduction in concentrations of DA in response to footshock, and a greater elevation in concentrations of metabolites of DA and/or metabolite/transmitter ratios, compared to nonhandled control rats. (2) In some regions of the brain repeated injections of saline produced changes in the response to subsequent footshock that were comparable to those produced by amphetamine. (3) Prior treatment with amphetamine enhanced theelease of [beta]-endorphin and N-acetylated [beta]-endorphin from the pituitary elicited by footshock stress. It is concluded that repeated intermittent treatment with amphetamine or stress (injections of saline) produce enduring changes in the response of DA neurons and the pituitary to subsequent stress. These changes may be responsible for the hypersensitivity to stress reported in former amphetamine addicts, and in rats previously sensitized to amphetamine. | en_US |
dc.format.extent | 2262350 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | The effects of footshock stress on regional brain dopamine metabolism and pituitary [beta]-endorphin release in rats previously sensitized to amphetamine | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Psychology and Neuroscience Laboratory Building, The University of Michigan, Ann Arbor, Michigan, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Psychology and Neuroscience Laboratory Building, The University of Michigan, Ann Arbor, Michigan, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Psychiatry and Mental Health Research Institute, The University of Michigan, Ann Arbor, Michigan, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Psychiatry and Mental Health Research Institute, The University of Michigan, Ann Arbor, Michigan, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Psychology and Neuroscience Laboratory Building, The University of Michigan, Ann Arbor, Michigan, U.S.A. | en_US |
dc.identifier.pmid | 2957606 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/26668/1/0000212.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0028-3908(87)90228-0 | en_US |
dc.identifier.source | Neuropharmacology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.