Cyclosporine augments reactivity of isolated blood vessels
dc.contributor.author | Lamb, Fred S. | en_US |
dc.contributor.author | Clinton Webb, R. | en_US |
dc.date.accessioned | 2006-04-07T19:52:10Z | |
dc.date.available | 2006-04-07T19:52:10Z | |
dc.date.issued | 1987-06-29 | en_US |
dc.identifier.citation | Lamb, Fred S., Clinton Webb, R. (1987/06/29)."Cyclosporine augments reactivity of isolated blood vessels." Life Sciences 40(26): 2571-2578. <http://hdl.handle.net/2027.42/26675> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T99-47796GB-NK/2/3462fe43b500a58acaac5545943a946a | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/26675 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3600170&dopt=citation | en_US |
dc.description.abstract | Administration of cyclosporine (CS) as an immunosuppressive agent in clinical transplantation is associated with multiple side effects including nephrotoxicity and hypertension. These two effects could be related in that the renal changes may be secondary to alterations in organ blood flow. The present studies investigate the ability of CS to augment contractile responsiveness in blood vessels from normotensive rats. Isometric force generation was measured in isolated tail arteries and portal veins. CS (8.3 x 10-6M) potentiated tail artery contractile responses to sympathetic nerve stimulation, exogenous norepinephrine, and increases in extracellular potassium concentration. Portal veins undergo spontaneous contractions which are related to the firing of calcium-driven action potentials in the smooth muscle cells. CS significantly increased the frequency of these spontaneous contractile events. These results suggest that components of CS toxicity may involve a direct action on vascular smooth muscle and/or on vascular adrenergic neurotransmission. | en_US |
dc.format.extent | 409499 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Cyclosporine augments reactivity of isolated blood vessels | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Physiology, University of Michigan, Ann Arbor, Michigan 48109-0622, USA | en_US |
dc.contributor.affiliationum | Department of Physiology, University of Michigan, Ann Arbor, Michigan 48109-0622, USA | en_US |
dc.identifier.pmid | 3600170 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/26675/1/0000219.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0024-3205(87)90080-4 | en_US |
dc.identifier.source | Life Sciences | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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