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Gamma-melanotropin response to ovine corticotropin releasing factor in normal humans
dc.contributor.authorMeador-Woodruff, James H.en_US
dc.contributor.authorWatson, Stanley J.en_US
dc.contributor.authorMurphy-Weinberg, Virginiaen_US
dc.contributor.authorJegou, Sylvieen_US
dc.contributor.authorVaudry, Huberten_US
dc.contributor.authorSeidan, Nabil G.en_US
dc.contributor.authorRivier, Jeanen_US
dc.contributor.authorVale, Wylie W.en_US
dc.contributor.authorAkil, Hudaen_US
dc.date.accessioned2006-04-07T19:53:43Z
dc.date.available2006-04-07T19:53:43Z
dc.date.issued1987en_US
dc.identifier.citationMeador-Woodruff, James H., Watson, Stanley J., Murphy-Weinberg, Virginia, Jegou, Sylvie, Vaudry, Hubert, Seidan, Nabil G., Rivier, Jean, Vale, Wylie, Akil, Huda (1987)."Gamma-melanotropin response to ovine corticotropin releasing factor in normal humans." Neuropeptides 9(4): 269-282. <http://hdl.handle.net/2027.42/26714>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WNR-4C48D17-MM/2/2a39a55df921e9302107f4cd99db1a9den_US
dc.identifier.urihttps://hdl.handle.net/2027.42/26714
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3497356&dopt=citationen_US
dc.description.abstractPlasma [gamma]-melanotropin was measured by a [gamma]3MSH-specific radioimmunoassay before and after a single bolus intravenous infusion of ovine corticotropin releasing factor (oCRF; 0.1 ug/kg) in seven normal men. A significant increase of [gamma]3MSH was observed 15 minutes post-oCRF infusion, which paralleled a similar increase in plasma cortisol. Bel filtration chromatography revealed that the observed increase was attributable to elevations of 9K and 4K forms of [gamma]3MSH immunoreactivity. Affinity chromatography demonstrated that the majority of [gamma]3MSH immunoreactivity in human plasma is glycosylated. As the smaller forms of [gamma]3MSH are felt to have endocrine activity at the adrenal cortex, these changes may be physiologically relevant.en_US
dc.format.extent936715 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleGamma-melanotropin response to ovine corticotropin releasing factor in normal humansen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbsecondlevelChemistryen_US
dc.subject.hlbsecondlevelChemical Engineeringen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelEngineeringen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumMental Health Research Institute, University of Michigan, Ann Arbor, Michigan 48109-0720, USA; Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109-0720, USA.en_US
dc.contributor.affiliationumDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109-0720, USA; Mental Health Research Institute, University of Michigan, Ann Arbor, Michigan 48109-0720, USA.en_US
dc.contributor.affiliationumDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109-0720, USA; Mental Health Research Institute, University of Michigan, Ann Arbor, Michigan 48109-0720, USA.en_US
dc.contributor.affiliationumDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109-0720, USA; Mental Health Research Institute, University of Michigan, Ann Arbor, Michigan 48109-0720, USA.en_US
dc.contributor.affiliationotherLaboratoire d'Endocrinologie, Faculte des Sciences et Techniques, Franceen_US
dc.contributor.affiliationotherLaboratoire d'Endocrinologie, Faculte des Sciences et Techniques, Franceen_US
dc.contributor.affiliationotherInstitut De Recherches Cliniques De Montreal, Clinical Research Institute of Montreal, Montreal, Canadaen_US
dc.contributor.affiliationotherClayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, CA 92037, USAen_US
dc.contributor.affiliationotherClayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, CA 92037, USAen_US
dc.identifier.pmid3497356en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/26714/1/0000264.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0143-4179(87)90002-3en_US
dc.identifier.sourceNeuropeptidesen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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