Pulsed Doppler assessment of left ventricular diastolic filling in coronary artery disease before and immediately after coronary angioplasty

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dc.contributor.author Wind, Barry E. en_US
dc.contributor.author Snider, A. Rebecca en_US
dc.contributor.author Buda, Andrew J. en_US
dc.contributor.author O'Neill, William W. en_US
dc.contributor.author Topol, Eric J. en_US
dc.contributor.author Dilworth, Lee R. en_US
dc.date.accessioned 2006-04-07T19:54:13Z
dc.date.available 2006-04-07T19:54:13Z
dc.date.issued 1987-05-01 en_US
dc.identifier.citation Wind, Barry E., Snider, A. Rebecca, Buda, Andrew J., O'Neill, William W., Topol, Eric J., Dilworth, Lee R. (1987/05/01)."Pulsed Doppler assessment of left ventricular diastolic filling in coronary artery disease before and immediately after coronary angioplasty." The American Journal of Cardiology 59(12): 1041-1046. <http://hdl.handle.net/2027.42/26727> en_US
dc.identifier.uri http://www.sciencedirect.com/science/article/B6T10-4C76DM6-1JC/2/17352e1c673656ea6b97dbe939e443b3 en_US
dc.identifier.uri http://hdl.handle.net/2027.42/26727
dc.identifier.uri http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2953227&dopt=citation en_US
dc.description.abstract To determine if left ventricular (LV) diastolic filling abnormalities are detectable by Doppler echocardiography in patients with coronary artery disease (CAD), 34 patients with CAD and 24 normal, agematched control subjects underwent mitral valve pulsed Doppler examination. At catheterization, all CAD patients had typical angina, at least 70% diameter narrowing of 1 major coronary artery, ejection fraction of 50% or more and no valvular heart disease. Seventeen CAD patients underwent coronary angioplasty and had a Doppler examination 1 day before and 1 day after the procedure. Doppler diastolic time intervals, peak velocities at rapid filling (E velocity), atrial contraction (A velocity) and the ratio peak E/peak A velocities were measured. The following areas under the Doppler velocity envelope and their percentage of the total area were calculated: first third of diastole (0.33 area), triangular area under the peak E velocity (E area), and triangular area under the peak A velocity (A area). Patients with CAD and normal subjects were significantly different (p &lt; 0.01) in peak E velocity (CAD 0.60 +/- 0.12 m/s, normal 0.68 +/- 0.12 m/s), peak A velocity (CAD 0.59 +/- 0.12 m/s, normal 0.48 +/- 0.11 m/s), ratio peak E/peak A velocities (CAD 1.0 +/- 0.27, normal 1.5 +/- 0.32), A area (CAD 0.052 +/- 0.015 m, normal 0.036 +/- 0.010 m), ratio E area/A area (CAD 1.7 +/- 0.53, normal 2.5 +/- 0.69), and all area fractions. In the CAD patients who had undergone coronary angioplasty, no differences were found in any Doppler index before and immediately after the procedure. Thus, abnormal patterns of LV diastolic filling occur in patients with CAD and normal global systolic function. The decreased percentage of the Doppler area occurring during rapid filling and the increased percentage of the Doppler area occurring in late diastole suggest that CAD patients have impaired early diastolic filling. These diastolic filling abnormalities are unimproved 24 hours after successful coronary angioplasty. Doppler echocardiography provides a useful, noninvasive technique for assessment of LV diastolic filling in patients with CAD. en_US
dc.format.extent 1107364 bytes
dc.format.extent 3118 bytes
dc.format.mimetype application/pdf
dc.format.mimetype text/plain
dc.language.iso en_US
dc.publisher Elsevier en_US
dc.title Pulsed Doppler assessment of left ventricular diastolic filling in coronary artery disease before and immediately after coronary angioplasty en_US
dc.rights.robots IndexNoFollow en_US
dc.subject.hlbsecondlevel Internal Medicine and Specialties en_US
dc.subject.hlbtoplevel Health Sciences en_US
dc.description.peerreviewed Peer Reviewed en_US
dc.contributor.affiliationum Departments of Pediatrics and Internal Medicine, Cardiology Divisions, University of Michigan Medical Center, Ann Arbor, Michigan, USA en_US
dc.contributor.affiliationum Departments of Pediatrics and Internal Medicine, Cardiology Divisions, University of Michigan Medical Center, Ann Arbor, Michigan, USA en_US
dc.contributor.affiliationum Departments of Pediatrics and Internal Medicine, Cardiology Divisions, University of Michigan Medical Center, Ann Arbor, Michigan, USA en_US
dc.contributor.affiliationum Departments of Pediatrics and Internal Medicine, Cardiology Divisions, University of Michigan Medical Center, Ann Arbor, Michigan, USA en_US
dc.contributor.affiliationum Departments of Pediatrics and Internal Medicine, Cardiology Divisions, University of Michigan Medical Center, Ann Arbor, Michigan, USA en_US
dc.contributor.affiliationum Departments of Pediatrics and Internal Medicine, Cardiology Divisions, University of Michigan Medical Center, Ann Arbor, Michigan, USA en_US
dc.identifier.pmid 2953227 en_US
dc.description.bitstreamurl http://deepblue.lib.umich.edu/bitstream/2027.42/26727/1/0000277.pdf en_US
dc.identifier.doi http://dx.doi.org/10.1016/0002-9149(87)90845-9 en_US
dc.identifier.source The American Journal of Cardiology en_US
dc.owningcollname Interdisciplinary and Peer-Reviewed
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