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Loss of hippocampal [3H]TCP binding in Alzheimer's disease

dc.contributor.authorMaragos, William F.en_US
dc.contributor.authorChu, Dorothy C. M.en_US
dc.contributor.authorYoung, Anne B.en_US
dc.contributor.authorD'Amato, Constance J.en_US
dc.contributor.authorPenney, Jr. , John B.en_US
dc.date.accessioned2006-04-07T19:55:51Z
dc.date.available2006-04-07T19:55:51Z
dc.date.issued1987-03-09en_US
dc.identifier.citationMaragos, William F., Chu, Dorothy C. M., Young, Anne B., D'Amato, Constance J., Penney, Jr., John B. (1987/03/09)."Loss of hippocampal [3H]TCP binding in Alzheimer's disease." Neuroscience Letters 74(3): 371-376. <http://hdl.handle.net/2027.42/26773>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T0G-482RVGV-27/2/1aceb62c11d174a30d929e0cfca1dfb5en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/26773
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3031556&dopt=citationen_US
dc.description.abstractWe have previously demonstrated a marked loss in (NMDA) receptors in the hippocampus and cerebral cortex of patients dying with dementia of the Alzheimer type (DAT). In addition, we have found that the dissociative anesthetic N-(1-[2-thienyl]cyclohexyl)3,4-piperidine ([3H]TCP) binds to a site whose regional distribution is highly correlated with that of NMDA receptor sites. We studied the binding of [3H]TCP to sections of hippocampi from 8 controls, 12 patients with DAT and 7 patients with other dementias. [3H]TCP binding was significantly reduced in strata pyramidalia of CA1/CA2, CA3 and subiculum of DAT hippocampal formation compared to that of control. Labelled dissociative anestheties could potentially be used with positron emission tomography in the diagnosis of DAT.en_US
dc.format.extent414772 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleLoss of hippocampal [3H]TCP binding in Alzheimer's diseaseen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelPsychologyen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelSocial Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of the Neuroscience Program, University of Michigan, Ann Arbor, MI 48104, U.S.A.en_US
dc.contributor.affiliationumDepartment of the Neuroscience Program, University of Michigan, Ann Arbor, MI 48104, U.S.A.en_US
dc.contributor.affiliationumDepartment of Neurology, University of Michigan, Ann Arbor, MI 48104, U.S.A.en_US
dc.contributor.affiliationumDepartment of Pathology, University of Michigan, Ann Arbor, MI 48104, U.S.A.en_US
dc.contributor.affiliationumDepartment of Neurology, University of Michigan, Ann Arbor, MI 48104, U.S.A.en_US
dc.identifier.pmid3031556en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/26773/1/0000325.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0304-3940(87)90326-0en_US
dc.identifier.sourceNeuroscience Lettersen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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