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Glutamate dysfunction in Alzheimer's disease: an hypothesis
dc.contributor.authorMaragos, William F.en_US
dc.contributor.authorGreenamyre, J. Timothyen_US
dc.contributor.authorPenney, Jr, John B.en_US
dc.contributor.authorYoung, Anne B.en_US
dc.date.accessioned2006-04-07T19:57:27Z
dc.date.available2006-04-07T19:57:27Z
dc.date.issued1987-02en_US
dc.identifier.citationMaragos, William F., Greenamyre, J. Timothy, Penney, Jr, John B., Young, Anne B. (1987/02)."Glutamate dysfunction in Alzheimer's disease: an hypothesis." Trends in Neurosciences 10(2): 65-68. <http://hdl.handle.net/2027.42/26817>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T0V-485YNFG-2J/2/a25655ac4d43ae3a530a081526627144en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/26817
dc.description.abstractGlutamate is a major excitatory neurotransmitter that has been implicated in memory formation and learning. This acidic amino acid also has neurotoxic properties, and in animals produces lesions reminiscent of human neurodegenerative diseases. Here we present evidence that supports the hypothesis that glutamate dysfunction is involved in the pathophysiology of Alzheimer's disease and can account for many of the neurochemical and behavioral deficits observed in this disease.en_US
dc.format.extent792317 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleGlutamate dysfunction in Alzheimer's disease: an hypothesisen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Neurology and the Neuroscience Program, University of Michigan, Ann Arbor, MI 48104, USAen_US
dc.contributor.affiliationumDepartment of Neurology and the Neuroscience Program, University of Michigan, Ann Arbor, MI 48104, USAen_US
dc.contributor.affiliationumDepartment of Neurology and the Neuroscience Program, University of Michigan, Ann Arbor, MI 48104, USAen_US
dc.contributor.affiliationumDepartment of Neurology and the Neuroscience Program, University of Michigan, Ann Arbor, MI 48104, USAen_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/26817/1/0000375.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0166-2236(87)90025-7en_US
dc.identifier.sourceTrends in Neurosciencesen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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