Arachidonic acid metabolism is altered in sarcoid alveolar macrophages,
dc.contributor.author | Bachwich, Peter R. | en_US |
dc.contributor.author | Lynch, III, Joseph P. | en_US |
dc.contributor.author | Kunkel, Steven L. | en_US |
dc.date.accessioned | 2006-04-07T19:58:54Z | |
dc.date.available | 2006-04-07T19:58:54Z | |
dc.date.issued | 1987-01 | en_US |
dc.identifier.citation | Bachwich, Peter R., Lynch, III, Joseph P., Kunkel, Steven L. (1987/01)."Arachidonic acid metabolism is altered in sarcoid alveolar macrophages,." Clinical Immunology and Immunopathology 42(1): 27-37. <http://hdl.handle.net/2027.42/26855> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WCK-4BJW3SS-1KF/2/29b335de02e37551fd81690999bff9f5 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/26855 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3098481&dopt=citation | en_US |
dc.description.abstract | Macrophages produce various arachidonic acid (AA) metabolites which may either enhance or suppress inflammatory processes. We investigated AA metabolite production by alveolar macrophages (AMs) from 11 patients with pulmonary sarcoidosis and 9 normal volunteers. We assessed the production of both cyclooxygenase products (prostaglandin (PG) E2, thromboxane B2 (TXB2), PGF2[alpha], and 6-keto-PGF1[alpha]) and lipoxygenase products (leukotrienes (LT) and hydroxyeicosatetraenoic acids (HETEs)) in AM cultures. We found that sarcoid AMs produced less PGE2, TXB2, 6-keto-PGF1[alpha], and HETEs in both the unstimulated and the calcium ionophore-stimulated states compared with normal AMs. Sarcoid AMs also produced less PGF2[alpha] and LTs in the unstimulated state after 1 hr of incubation, but following calcium ionophore stimulation, these differences did not achieve statistical significance. We conclude that sarcoid AMs have a reduced capacity to produce AA metabolites compared with that of normal AMs. | en_US |
dc.format.extent | 889708 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Arachidonic acid metabolism is altered in sarcoid alveolar macrophages, | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Microbiology and Immunology | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA. | en_US |
dc.contributor.affiliationum | Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA; Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA. | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA. | en_US |
dc.identifier.pmid | 3098481 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/26855/1/0000420.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0090-1229(87)90170-X | en_US |
dc.identifier.source | Clinical Immunology and Immunopathology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.