Prostacyclin protects ischemic reperfused myocardium in the dog by inhibition of neutrophil activation
dc.contributor.author | Simpson, Paul J. | en_US |
dc.contributor.author | Mitsos, Stephanie E. | en_US |
dc.contributor.author | Ventura, Anthony | en_US |
dc.contributor.author | Gallagher, Kim P. | en_US |
dc.contributor.author | Fantone, Joseph C. | en_US |
dc.contributor.author | Abrams, Gerald D. | en_US |
dc.contributor.author | Schork, M. Anthony | en_US |
dc.contributor.author | Lucchesi, Benedict Robert | en_US |
dc.date.accessioned | 2006-04-07T20:00:12Z | |
dc.date.available | 2006-04-07T20:00:12Z | |
dc.date.issued | 1987-01 | en_US |
dc.identifier.citation | Simpson, Paul J., Mitsos, Stephanie E., Ventura, Anthony, Gallagher, Kim P., Fantone, Joseph C., Abrams, Gerald D., Schork, M. Anthony, Lucchesi, Benedict R. (1987/01)."Prostacyclin protects ischemic reperfused myocardium in the dog by inhibition of neutrophil activation." American Heart Journal 113(1): 129-137. <http://hdl.handle.net/2027.42/26892> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6W9H-4BYSTWM-PW/2/88ca7ebd80d380eba969b2056369f4c4 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/26892 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3541554&dopt=citation | en_US |
dc.description.abstract | Prostacyclin (PGI2) and the stable PGI2 analogue SC39902 (6,9[alpha]-epoxy, 5S-fluoro-11[alpha], 15S-dehydroxyprosta-6, 13E-dien-1-oic acid, sodium salt) were studied in anesthetized open-chest dogs subjected to 90 minutes of left circumflex coronary artery (LCCA) occlusion and 6 hours of reperfusion. PGI2 (50 ng/kg/min, infused into the left atrium) reduced infarct mass by 59% compared to control, but SC39902 (1.5 [mu]g/kg/min) failed to produce a significant reduction in infarct size. Both PGI2 and SC39902 reduced mean arterial blood pressure, heart rate, and rate-pressure product to the same extent. Regional myocardial blood flow measured with radiolabelled tracer microspheres did not demonstrate an increase in regional blood flow to the ischemic myocardium during the 90 minutes of LCCA occlusion in the PGI2 and control treatment groups. Canine neutrophils were isolated from whole blood and activated with opsonized zymosan. PGI2 produced a concentration-dependent inhibition of neutrophil activation as measured by superoxide production in vitro, whereas SC39902 failed to effectively inhibit neutrophil activation. Neutrophil migration into inflammatory skin lesions was effectively attenuated when dogs were pretreated with PGI2 (50 ng/kg/min, intravenously). Therefore, it is suggested that the cytoprotective effect of PGI2 during myocardial ischemia and reperfusion is related to an inhibition of neutrophil migration and the production of cytotoxic activated oxygen species. | en_US |
dc.format.extent | 1123886 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Prostacyclin protects ischemic reperfused myocardium in the dog by inhibition of neutrophil activation | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pharmacology The University of Michigan Medical School, Ann Arbor, Mich., USA | en_US |
dc.contributor.affiliationum | Department of Pharmacology The University of Michigan Medical School, Ann Arbor, Mich., USA | en_US |
dc.contributor.affiliationum | Department of Pharmacology The University of Michigan Medical School, Ann Arbor, Mich., USA | en_US |
dc.contributor.affiliationum | Department of Physiology The University of Michigan Medical School, Ann Arbor, Mich., USA | en_US |
dc.contributor.affiliationum | Department of Pathology The University of Michigan Medical School, Ann Arbor, Mich., USA | en_US |
dc.contributor.affiliationum | Department of Pathology The University of Michigan Medical School, Ann Arbor, Mich., USA | en_US |
dc.contributor.affiliationum | The School of Public Health,University of Michigan, Ann Arbor, Mich., USA; Department of Biostatistics, The University of Michigan Medical School, Ann Arbor, Mich., USA. | en_US |
dc.contributor.affiliationum | Department of Pharmacology The University of Michigan Medical School, Ann Arbor, Mich., USA. | en_US |
dc.identifier.pmid | 3541554 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/26892/1/0000458.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0002-8703(87)90020-2 | en_US |
dc.identifier.source | American Heart Journal | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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