Cryoprobe-induced apical lesions in the chinchilla. II. Effects on behavioral auditory thresholds
dc.contributor.author | Smith, D. W. | en_US |
dc.contributor.author | Brown, J. Nadine | en_US |
dc.contributor.author | Moody, David B. | en_US |
dc.contributor.author | Stebbins, William C. | en_US |
dc.contributor.author | Nuttall, Alfred L. | en_US |
dc.date.accessioned | 2006-04-07T20:02:00Z | |
dc.date.available | 2006-04-07T20:02:00Z | |
dc.date.issued | 1987 | en_US |
dc.identifier.citation | Smith, D. W., Brown, J. N., Moody, D. B., Stebbins, W. C., Nuttall, A. L. (1987)."Cryoprobe-induced apical lesions in the chinchilla. II. Effects on behavioral auditory thresholds." Hearing Research 26(3): 311-317. <http://hdl.handle.net/2027.42/26941> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T73-485GKK2-DG/2/2ad97b316e59e62f7afae706d00f573e | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/26941 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3583931&dopt=citation | en_US |
dc.description.abstract | Lesions of the hair cells in the cochlear apex were produced by a miniature cryoprobe and changes in behavioral auditory thresholds were measured. Monauralized adult chinchillas were behaviorally trained using operant procedures to produce pure-tone audiograms at frequencies from 63 Hz to 40 kHz. Following collection of baseline thresholds, the apical and middle turns of the experimental ear were visualized through a hole drilled in the bulla and a copper cryoprobe that had been cooled in liquid nitrogen was placed on the apical turn of the cochlea. Post-lesion threshold shifts from two subjects showed a flat loss of approximately 20 dB restricted to frequencies below either 710 Hz or 1 kHz; thresholds were normal at higher frequencies. The cytocochleograms, prepared from the ears following completion of threshold testing, show an almost complete loss of both inner and outer hair cells in the apical-most 20% of the cochlea with an abrupt transition region to areas of normal-looking hair cell populations. The relationship between the frequencies at which hearing was impaired and the location of missing hair cells along the basilar membrane is in agreement with the frequency-place map for the chinchilla of Eldredge et al. [(1981) J. Acoust. Soc. Am. 69, 1091-1095]. The magnitude of the loss, however, is less than might be expected based on comparison with threshold shifts produced by similar pathology in the basal turns. | en_US |
dc.format.extent | 666251 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Cryoprobe-induced apical lesions in the chinchilla. II. Effects on behavioral auditory thresholds | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, University of Michigan Medical School, Ann Arbor, U.S.A.; Dept. of Psychology, University of Michigan Medical School, Ann Arbor, U.S.A. | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, University of Michigan Medical School, Ann Arbor, U.S.A. | en_US |
dc.contributor.affiliationum | Dept. of Psychology, University of Michigan Medical School, Ann Arbor, U.S.A.; Kresge Hearing Research Institute, University of Michigan Medical School, Ann Arbor, U.S.A. | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, University of Michigan Medical School, Ann Arbor, U.S.A.; Kresge Hearing Research Institute, University of Michigan Medical School, Ann Arbor, U.S.A.; Dept. of Psychology, University of Michigan Medical School, Ann Arbor, U.S.A. | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, University of Michigan Medical School, Ann Arbor, U.S.A. | en_US |
dc.identifier.pmid | 3583931 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/26941/1/0000507.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0378-5955(87)90066-9 | en_US |
dc.identifier.source | Hearing Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.