Reorganization of cerebellar cell suspension transplanted into the weaver mutant cerebellum and immunohistochemical detection of synaptic formation
dc.contributor.author | Kohsaka, Shinichi | en_US |
dc.contributor.author | Takayama, Hideichi | en_US |
dc.contributor.author | Ueda, Tetsufumi | en_US |
dc.contributor.author | Toya, Shigeo | en_US |
dc.contributor.author | Tsukada, Yasuzo | en_US |
dc.date.accessioned | 2006-04-07T20:06:44Z | |
dc.date.available | 2006-04-07T20:06:44Z | |
dc.date.issued | 1988-12 | en_US |
dc.identifier.citation | Kohsaka, Shinichi, Takayama, Hideichi, Ueda, Tetsufumi, Toya, Shigeo, Tsukada, Yasuzo (1988/12)."Reorganization of cerebellar cell suspension transplanted into the weaver mutant cerebellum and immunohistochemical detection of synaptic formation." Neuroscience Research 6(2): 162-166. <http://hdl.handle.net/2027.42/27026> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T0H-485GJTV-8N/2/9c53c177ded0c9ba274871ef6e3ade9d | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/27026 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3146036&dopt=citation | en_US |
dc.description.abstract | Dissociated cells prepared from the cerebellar primordia of normal 15-day mouse embryos were grafted into the cerebellum of 1-month-old weaver mutant mice which are characterized by degeneration of cerebellar granule cells during the early postnatal period. The growth of the grafted cells was investigated at 1 month after the operation. Implanted cells were highly developed to form a large mass of tissue in the host cerebellar folia. Histological examination revealed that a trilaminar cortical structure was partially developed in certain areas of the grafted tissue. The implanted granule-like cells were labeled with [3H]thymidine which was injected into the host, suggesting that the granule-like cells actively proliferate in the host cerebellum after the transplantation. In this area, strong immunoreactivity with synapsin I was detected indicating that the dissociated granule cells of the cerebellar primordia are able to develop a synaptic organization in the weaver mouse cerebellum. | en_US |
dc.format.extent | 585891 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Reorganization of cerebellar cell suspension transplanted into the weaver mutant cerebellum and immunohistochemical detection of synaptic formation | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Mental Health Research Institute, The University of Michigan, Ann Arbor, MI, U.S.A. | en_US |
dc.contributor.affiliationother | Department of Physiology, School of Medicine, Keio University, Tokyo, Japan | en_US |
dc.contributor.affiliationother | Department of Neurosurgery, School of Medicine, Keio University, Tokyo, Japan | en_US |
dc.contributor.affiliationother | Department of Neurosurgery, School of Medicine, Keio University, Tokyo, Japan | en_US |
dc.contributor.affiliationother | Department of Physiology, School of Medicine, Keio University, Tokyo, Japan | en_US |
dc.identifier.pmid | 3146036 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/27026/1/0000014.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0168-0102(88)90018-1 | en_US |
dc.identifier.source | Neuroscience Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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